本研究利用生物可降解性高分子與奈米黏土摻混物複合材料製成生物可降解性高分子腸套管，植入於第二型糖尿病肥胖大鼠十二指腸中，改善其體重與血糖，達到治療第二型糖尿病以及肥胖的效果。肥胖及第二型糖尿病為近年來越趨嚴重的醫療問題，而目前治療肥胖及肥胖所導致第二型糖尿病，外科手術是目前對於病態性肥胖病人較為有效治療方法，其目的在改變消化道結構與操縱胃腸生理運行，然而如此侵入式的治療會對於病患生理以及心理層面產生較大傷害，因此開發非侵入性治療用來治療肥胖及第二型糖尿病具有其重要性。聚己內酯與聚乳酸是現今普遍應用於生醫方面的高分子材料，兩者皆具有良好的生物相容性以及生物可降解的特性，並且皆具有不錯的機械性質，因此本研究將聚己內酯與聚乳酸摻混奈米黏土Laponite®，探討不同比例的高分子以及Laponite®在複合材料中的交互作用，以及不同比例的複合材料所增強的機械性質，在拉伸測試中提升最強的拉伸強度增加了109%。第二型糖尿病肥胖大鼠在植入高分子腸套管四周後腸套管的位移程度不一，而體重以及血糖均較控制組之第二型糖尿病肥胖大鼠有明顯的改善，組織病理切片報告則未有急性的發炎症狀。

This research aim to control body weight and blood glucose of diabetic obesity rats by implant biodegradable polymer duodenal barrier, which is made by polycaprolactone/poly(D,L-lactic acid) blend clay nanocomposite. Obesity and type II diabetes is the serious medical problems in recent years. Surgery is still the gold-standard treatment for morbid obesity and obesity related type II diabetes, which changes the structure of the digestive tract and gastrointestinal physiology. But surgical risk and complication may cause the physiological and psychological stress of patients. Non-invasive therapy may be an alternative treatment for obesity and diabetes mellitus. Some research have already proved that implants a barrier, covering partial of the duodenum can alter intestinal hormones and reduce body weight and blood glucose. Polycaprolactone and poly(D,L-lactic acid) are two well-known biodegradable polymer, having great biocompatibility and fine mechanical properties. To enhance the mechanical properties of biodegradable polymer, polycaprolactone and poly(D,L-lactic acid) blend with nano-clay Laponite® under different content ratio. PCL/PDLLA/Laponite® nanocomposite has largest improvement of 109% in tensile test. Four weeks after duodenal barrier implant in intestine of diabetic obesity rats, body weight and blood glucose both have obvious improvement. Histopathological section report showed no acute symptoms of inflammation.

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