近年來，大規模事故頻傳，常伴隨出血、組織液流失等現象，當失血過多時，常造成休克，嚴重則是死亡，這大量出血可稱為”未獲控制之大出血”，這也是主要致死原因之一，因此，如何在第一時間促使傷口快速止血，是極其重要之一步。
此外，在一般常見的導管手術，如血管攝影或心導管支架手術，而接受此手術患者，大多是正在接受抗凝血劑治療(如中風、心肌梗塞)，因此對此類患者來說，止血又是極為重要的環節。
故本研究開發一種以蠶絲為基材之具抗沾黏與高吸收性的加壓止血貼，藉由蛋白酶的作用，將大分子蠶絲蛋白降解為小分子蠶絲蛋白，改變在水中的溶解度，並添加氯化鈣加速傷口凝血，而所製備的止血貼對3T3細胞並無毒性，且對於PRP具有凝集效果，未凝集程度為33.6 ± 13.15%，從SEM中可看見，血小板被活化且出現網狀結構的纖維蛋白，而且所製備的加壓止血貼，在使用2小時後，壓力值仍高於平均收縮壓，故能進行長期加壓止血，另外在止血效果方面，在未加壓下，所用止血時間為102.5 ± 5.57秒；在加壓下則只需60秒，其止血效果都優於市售所販售的加壓止血貼，且敷料沾黏程度為0，故不會造成皮膚二次傷害，且敷料的吸收性從每單位敷料所吸收血量與敷料切片來看，在未加壓0-300秒後，降解組為7.8 ± 0.75；市售組為4.3 ± 0.28，效果也較市售所販售之加壓止血貼好，因此本實驗所開發的具抗沾黏與高吸收性的加壓止血貼，不論在臨床或日常生活上，都具備使傷口加速止血之潛力。

In this study, we developed a compressed foam patch with anti-adhesive and high-absorption performance using silk fibroin protein. By using the protease, the macromolecular silk fibroin protein was degraded into small molecule silk protein, and the solubility in water was greatly enhanced. Furthermore, we added calcium chloride to chelate the amino group and accelerate wound coagulation. The cytotoxicity test of a compressed foam path toward 3T3 fibroblast cells showed 80% cell viability which indicated that the compressed foam path had no significant cytotoxicity toward skin cells. The compressed foam path showed an agglutinating effect on PRP which the degree reached 33.6 ± 13.15% of non-agglutination. From the SEM image, we observed that the platelets were activated and the structure of the fibrin was reticulated. When we used the compressed foam path for 2 hours, the pressure value was still higher than the average systolic pressure. On the hemostatic effect, the hemostasis time was 102.5 ± 5.57 seconds under no compressed pressure; when compressed pressure was provided, it only took 60 seconds to stop the blood bleeding, so the hemostasis effect was better than the commercial product.The adhesion degree was 0, so it was expected to reduce the secondary damage to the skin. From the absorption of blood per unit dressing and the dressing slice, the absorption of our foam path was better than the commercial foam path, which showed that our foam path was 7.8 ± 0.75 and the commercial foam path was 4.3 ± 0.28 under no compressed pressure for 0-300 seconds respectively.

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