超分子聚合物的發展為將藥物運送至身體特定目標區域提供了一個良好的機制，有助於減少放射治療引起的副作用，同時也鼓勵研究人員專注於化學治療方法。由核鹼基衍生的超分子聚合物能在水溶液中快速自組裝為奈米級材料，具有可調節的可逆性和結構穩定性等獨特物理性質，使其適用於藥物傳遞系統。然而，設計和開發多刺激響應的核鹼基功能化超分子聚合物仍然是一項重大挑戰，同時實現所需的物理化學性質並將其應用於藥物傳遞系統也面臨著相當的困難。此外，另一項重大挑戰是設計、操作和控制金屬介導的核鹼基功能化鹼基對超分子奈米顆粒以及光反應性的金屬介導的核鹼基功能化鹼基對超分子奈米顆粒，以獲得所需的物理性質，從而能夠在微型腫瘤環境條件下實現高度可控的共軛奈米顆粒解離和金屬離子的選擇性釋放。
因此，在本篇論文中，我們設計並合成了具有雙功能的胞嘧啶終止超分子聚合物和以汞介導的尿嘧啶功能化鹼基對超分子聚合物，兩者均成功地以所需的產率獲得。在紫外線照射下，胞嘧啶和尿嘧啶會形成光二聚體，使得胞嘧啶功能化超分子聚合物和汞介導的尿嘧啶功能化鹼對超分子奈米顆粒能夠形成光交聯結構並在水溶液中自發自組裝。此外，具有光反應性的胞嘧啶功能化超分子聚合物與經紫外線照射的金屬共軛超分子奈米顆粒共享獨特的性質，包括所需的奈米級尺寸、球形形態、優越的結構穩定性和在水溶液中對pH的敏感性。更重要的是，體外研究證實，載有藥物的微胞中的光二聚化的Cy-PPG聚合物和U-Hg-U超分子奈米顆粒（無需使用游離藥物或螢光探針）與未照射的超分子奈米顆粒相比，顯著增強了它們在細胞內的內吞作用和對癌細胞的大量凋亡。

The development of supramolecular polymers, which carry and transport drugs to specific target spots within the body, offers a good mechanism to minimize the side effects addressed by radiotherapy and encourages researchers to focus on chemotherapeutic treatment approaches. Supramolecular polymers derived from nucleobases enable them to rapidly self-assemble into nano-size materials in an aqueous solution, resulting in unique physical properties such as tunable reversibility and structural stability, making them suitable for use in drug delivery systems. While designing and developing multi-stimuli-responsive nucleobase-functionalized supramolecular polymers remains a significant challenge, achieving the required physico-chemical properties and making them applicable in drug delivery systems also remains a significant challenge. Moreover, another significant challenge is the design, manipulation, and control of metal-mediated nucleobase functionalized base pair supramolecular nanoparticles and photo-reactive metal-mediated nucleobase functionalized base pair supramolecular nanoparticles with desired physical properties that allow for a high level of well-controlled dissociation of the conjugated nanoparticles and controlled release of the metal ions in selective cancer cells under micro-tumor environmental conditions. As a result, in this dissertation, we designed and synthesized bi-functional cytosine-terminated supramolecular polymers and mercury-mediated uracil functionalized base pair supramolecular polymers, both of which were successfully obtained at the required yield. The presence of cytosine and uracil photodimers induced by UV irradiation, cytosine-functionalized supramolecular polymers, and mercury-mediated uracil-functionalized base pairs supramolecular nanoparticles can form photo-cross-linked structures and spontaneously self-assemble in aqueous solutions. Furthermore, photo-reactive cytosine-functionalized supramolecular polymers shared unique properties with irradiated metallo-conjugated supramolecular nanoparticles, including desired nanosize, spherical morphology, excellent structural stability, and pH responsiveness in aqueous solution. More importantly, in vitro studies confirmed that photo-dimerized Cy-PPG polymer within drug-loaded micelles and U-Hg-U supramolecular nanoparticles (without using free drugs or fluorescence probes) significantly enhanced their internalization and massive apoptotic cancer cell death compared to non-irradiated supramolecular nanoparticles.

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