骨質疏鬆症是一種與年齡相關的常見疾病，它會使骨骼的質量密度降低，而其造成的原因可能為更年期或是身體吸收的能力下降，由於此種疾病不易在發病初期發現，因此唯一的治癒方法即是外科手術，然而，外科手術後可能會會引發一種稱為手術部位感染 (SSI)的細菌感染，此外，當骨骼中的鍶 (Sr) 含量減少時，也會引發骨質疏鬆症，因為鍶具有透過抑制破骨細胞來促進程骨細胞生長的能力，故一種具有抵抗細菌活性，且能夠促進成骨細胞再生的生物材料是現今所必須的。
本研究利用噴霧熱裂解法製備含有1.64mol%銀 (Ag) 和1、5及10mol% 鍶 (Sr) 的介孔生物活性玻璃 (MBG)，所獲得之樣品將會利用X光繞射儀 (X-ray diffractometer, XRD)、掃描式電子顯微鏡 (Scanning Electron Microscope, SEM)、比表面積與孔隙度分析儀 (Specific Surface Area and Porosity Analyzer, BET)、抗菌測試、細胞存活性測試 (MTT assays) 、鹼性磷酸酯活性 (Alkaline Phosphatase, ALP) 和生物活性測試，做性質分析。
實驗結果顯示，在含銀的介孔生物活性玻璃中添加鍶可以增強抗菌能力、細胞存活率和氫氧基磷灰石的生成速率，儘管在含鍶介孔生物活性玻璃的實驗中，添加10mol%鍶的介孔生物活性玻璃粉末浸泡在SBG中24h，會稍微延遲氫氧機磷灰石的生成，不過多項研究已經證明，在含銀介孔生物活性玻璃中，添加適量的鍶可以增強其抗骨質疏鬆的能力，並降低術後手術部位受感染的可能性。

Osteoporosis is a well-known age-related disease that happens when the bone loses its mass density, it could be from menopause or when our body absorption ability is decreased. Due to difficulties to detect this disease in the early phase, the only way to cure is bone surgery. However, there are several cases of bacterial infection after surgery which called surgical site infection (SSI). Also, osteoporosis happens when the amount of Sr in our bone is decreasing. Sr has the ability to promotes osteoblast cells by inhibiting the osteoclast. Thus, a biomaterial with ability against bacterial activity and able to promote osteoblast cells for bone regeneration is needed.
In this study, the spray pyrolysis (SP) method was used to prepare mesoporous bioactive glass (MBG) contained with 1.64 mol% silver (Ag) and 1, 5, and 10 mol% strontium (Sr) concentrations. Then, samples were characterized by using x-ray diffraction (XRD), scanning electron microscope (SEM), nitrogen adsorption/desorption (BET), antibacterial test, cell viability test (MTT assays), alkaline phosphate (ALP) activity and in-vitro bioactivity test.
The results show that the addition of Sr on Ag-containing MBG powders enhanced the antibacterial test, cell viability, and hydroxylapatite formation rate. Although, in the Sr-MBG case, the addition of 10 mol% slightly retarding the hydroxylapatite formation after powders immersed into SBG for 24 h. Nonetheless, in the appropriate amount of addition, Sr has proven to enhance the ability Ag-containing MBG powders to be a promising material for anti-osteoporosis and reducing the probability of surgical site infection.

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