金屬有機框架 (MOF) 已被廣泛應用於生物醫學。然而，由於前體材料和合成溶劑選擇不當而導致的生物不相容性問題仍然是一個需要解決的挑戰。在本研究中，在鹼調節條件下，兩種具有不同酰基鍊長度的生物活性有機連接體，即原兒茶酸 (PCA) 和二氫咖啡酸 (DHCA)，被用於製備銅基生物 MOFs (BioMOFs)，分別表示為 Cu-PCA 和 Cu-DHCA。粉末 X 射線衍射 (XRD)的詳細晶體分析數據顯示，Cu-PCA (C14H16O13Cu3) 在空間群 P1 中結晶為三斜晶，而 Cu-DHCA (C68H73O36Cu12) 在空間群 P422 中合成為四方晶體。使用傅里葉變換紅外 (FTIR)、掃描電子顯微鏡 (SEM)、X 射線光電子能譜 (XPS)、熱重分析 (TGA)、元素分析 (EA) 和氮氣 (N2) 吸附探討所合成的 BioMOF間的詳盡物理化學差異。 N2吸附分析顯示，使用具有較長酰基鍊長的有機接頭製備的Cu-DHCA具有擴大的孔徑；比 Cu-PCA 大 2.29 倍。 Cu-DHCA 還顯示最大利福平 (RIF) 載藥量為 559.40 mg/g，比 Cu-PCA 高 1.26 倍。在模擬生理條件的磷酸鹽緩衝鹽水溶液中重新懸浮後，RIF 和接頭釋放表現出兩相釋放動力學曲線，雙相劑量反應 (BiDoseResp) 模型可對此做很好的描述。 BioMOFs 及其負載 RIF 的類似物對大腸桿菌具有抗菌活性，並且被證明為無細胞毒性，此可經由補充後 MH-S 小鼠肺泡巨噬細胞的高活力所驗證。因此，這些 BioMOFs 經證明為一種很有潛力的 RIF 載體，通過延長有機接頭的酰基鍊長度可以增強其載藥能力。

Metal-organic frameworks (MOFs) have been widely explored for biomedical applications. However, the issue of bio-incompatibility that comes from the improper selection of precursor materials and synthesis solvents remains a challenge that needs to be tackled. In this study, two biologically active organic linkers with different acyl chain lengths, namely protocatechuic acid (PCA) and dihydrocaffeic acid (DHCA), were used to prepare copper-based biological MOFs (BioMOFs), denoted Cu-PCA and Cu-DHCA, respectively, under base-modulated conditions. Detailed crystal analysis based on the powder X-Ray Diffraction (XRD) data demonstrated that the Cu-PCA (C14H16O13Cu3) crystalizes as triclinic in space group P1 and Cu-DHCA (C68H73O36Cu12) synthesized as a tetragonal crystal in space group P422. Comprehensive physicochemical differences between the synthesized BioMOFs were investigated using Fourier Transform Infrared (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), elemental analysis (EA), and nitrogen (N2) sorption.
The N2 sorption analysis shows that Cu-DHCA, prepared using the organic linker with a longer acyl chain length, has an enlarged pore diameter; that is 2.29-fold greater than the Cu-PCA. The Cu-DHCA also showed maximum rifampicin (RIF) drug loading of 559.40 mg/g, which is 1.26-fold higher than Cu-PCA. Upon resuspension in a phosphate-buffered saline solution that mimics physiological condition, the RIF and linkers release exhibit two-phase release kinetic profiles, which are well described by the Biphasic Dose Response (BiDoseResp) model. BioMOFs and their RIF-loaded analog possessed antibacterial activity against Escherichia coli and were proven to be non-cytotoxic, as evidenced by the high viability of MH-S mice alveolar macrophage cells upon supplementation. Hence, these BioMOFs were demonstrated as a promising RIF carrier, with enhanced drug loading ability achievable by extending the acyl chain length of the organic linker.

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