本研究目的為評估以新型經皮給藥儀－liquid medication dispenser (LMD)經由皮膚滲透傳遞模式藥物(diclofenac sodium)，LMD給藥儀是一台以氣體壓力將液體藥物傳輸進入皮膚達到局部鎮痛效果。
評估LMD給藥儀的性質及特性，包括LMD給藥儀的最佳氣體壓力、滲透深度、經皮滲透累積量以及動物試驗之局部鎮痛效果。利用仿體得知LMD給藥儀的最佳氣體壓力為100 psi；在豬耳皮的滲透深度方面，氣體壓力100 psi注射50發可達136.44±10.90 μm及100發可達165.43±7.19 μm；於diclofenac sodium經皮滲透累積滲透量方面，有使用LMD給藥儀的組別相較於控制組增加了39%，且滲透流量比控制組多33%及遲滯時間減少12%；最後，大鼠腳掌熱痛閾值測試中，以LMD給藥儀給予diclofenac sodium，藥物效能可持續到60分鐘。
由研究結果得知，LMD給藥儀確實能克服皮膚角質層的屏障及增加藥物滲透能力；由動物實驗中證實，LMD給藥儀搭載diclofenac sodium確實能局部給藥達到局部鎮痛效果。LMD給藥儀具有很大的潛力運用在局部經皮給藥系統。

An novel transdermal drug delivery device (liquid medication dispenser, LMD) used to evaluate skin permeability of model drug (diclofenac sodium). It’s a machine combining with gas pressure offer a new effective deliver drug to skin for local analgesic therapy.
The optimal condition of the LMD including the optimal gas pressure and the permeation depth was evaluated. The diffusion model (Franz static diffusion cell) used to evaluate the skin permeation cumulative amount profile. And in vivo local analgesic effects were evaluated in animal model.
Using the agar block model, the optimal gas pressure of LMD is 100 psi, which resulted in the permeation depth of porcine ear skin 136.44±10.90 μm (50 shots) and 165.43±7.19 μm(100 shots). In skin permeation of diclofenac sodium cumulative amount study, the LMD group increased 39%, steady state flux increased 33% and lag time decreased 12% compare to control group (no treatment). In rat’s plantar test, the effect of local analgesic persisted in 60 minutes in LMD group.
Our results showed that LMD can overcome stratum corneum and enhance skin permeability. In animal test, LMD can be used in local therapy. The LMD have great potential to local transdermal drug delivery system.

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