高透氧硬性隱形眼鏡 (rigid gas permeable contact lens, RGP lens)，以下簡稱RGP，RGP主要是由氟矽丙烯酸酯 (Fluoro-silicone acrylate, FSA) 組成。RGP可有效矯正不同類型的屈光不正，RGP表面通常具疏水性質，因此在配戴RGP者眨眼後，淚液無法完全均勻地分布在RGP表面，同時也可能因脂質和蛋白質沉積物沉積，造成眼睛的不適。本研究利用真空電漿改質法並優化參數：電漿功率、處理時間、氣體流率及腔體壓力再經由RGP表面水接觸角的測量與探討RGP的儲存環境對親水性的影響。經再現性實驗顯示最適化後的電漿參數是：80 W /120 s /10 sccm / 100 mTorr。在評估儲存環境對經電漿改質RGP表面親水性的影響，本論文在探討儲存環境時發現低溫、生理食鹽水與含有親水因子的多功能護理液(MPS)中可延長RGP表面的親水性，但即使將電漿改質後的RGP儲存在低溫及MPS，經過30天觀察期後RGP表面的水接觸角仍因疏水性回復至約60°。
電漿改質產生的親水性效果通常會因疏水性回復在一段時間後失效，因此本論文第二部分應用UV誘導化學接枝與化學氣相沉積法製備薄膜於RGP表面，以達長期的親水性與抗沾黏效果。在UV誘導N-乙烯基-2-吡咯酮 (N-vinyl-2-pyrrolidone, NVP) 及甲基丙烯酸聚乙二醇酯 (poly (ethylene glycol)methacrylate, PEGMA) 聚合接枝於RGP表面方面，可增加RGP表面的親水性且不會影響其生物相容性。經過120天的觀察期水接觸角為27°。本實驗將誘導NVP/PEGMA聚合接枝的RGP進行生物相容性測試、物性及化性的分析，實驗結果顯示誘導NVP/PEGMA聚合接枝的RGP不會改變其生物相容性、物性及化性，經統計學one-way ANOVA分析結果無顯著差異。在利用化學輔助氣相沉積法 (PECVD) 方面，將PEGMA/NVP沉積在RGP表面，同樣經120天的觀察期，其水接觸角為24°且PECVD的膜層較UV誘導聚合接枝更均勻並能減少廢液的產生對環境的影響更少。

Rigid gas permeable (RGP) contact lenses are composed mainly of fluorosilicone acrylates (FSA) / with polymethyl methacrylate (PMMA). The surface of RGP contact lens is generally hydrophobic; therefore, after blinking, the tear cannot be spread evenly over the surface of the lens surface and this will result in discomfort for the eye. Low-temperature plasma is one of the most commonly applied methods to increase the surface hydrophilicity of the RGP contact lens. However, plasma treated lenses often were reported to have problems of aging and hydrophobicity recovery within a certain period of time after treatement. Protein ans lipids deposited on RGP contact lenses are due to the equilibrium state of surface hydrophobicity and hydrophilicity of materials. Therefore, this study aims to apply argon plasma and N-vinyl-2- pyrrolidone (NVP) / poly (ethylene glycol methyl ether methacrylate) (PEGMA) coatings on contact lens to investigate the changes on lens surface properties.
In this study, the wettability of the contact lens treated by argon plasma was investigated by water contact angle measurements to find the optimum storage conditions (temperature and environment) and plasma treatment parameters (applied power, flow rate, pressure, and treatment time). Additionally, the effects of the storage time on surface wettability of lens were evaluated after 30 days of storage. The correlations between hydrophobicity recovery and plasma parameters showed that optimized plasma treatment conditions were with 80 W argon plasm, 120 seconds treatment, by using 10 sccm flow rate under 100 mTorr. However, even through RGP was plasma treated with this optimized parameter, the water contact angle on the surface of RGP increased from 37° at day one to 59° at day 7 because of hydrophobic recovery.
The FTIR analyses confirmed that there was no significant difference between the surface of RGP before and after argon plasma treatment. Based on ISO 18369-4, the results of polarographically for oxygen transport showed that there was no significant difference for DK, light transmittance, cytotoxicity, and cell viability. Moreover, protein adsorption and antibacterial potency tests show significant reduction of adsorbed protein, and no inhibition efficacy toward Staphylococcus Aureus.
In addition to plasma treatment, this study also applied UV induced grafting polymerization (UV-IGP) and plasma enhanced chemical vapor deposition (PECVD) of NVP/PEGMA to promote hydrophilicity and resistance to protein and bacteria on RGP. FTIR analysis confirmed the success of graft polymerization of NVP and PEGMA on the surface of RGP contact lens. Moreover, the cytotoxicity and cell viability of the NVP/PEGMA grafted RGP contact lenses were evaluated by cultivation of L-929 fibroblasts and through lactic dehydrogenase (LDH) assays.
The preliminary results showed that on the grafted RGP contact lens there was a significant reduction of adsorbed protein. In addition, PEGMA grafted RGP showed better efficacy for the reduction of protein adsorption than the NVP grafted ones. In addition, the antibacterial tests performed on the treated RGP contact lens exhibited inhibition efficacy toward the growth of Staphylococcus Aureus. This study shows great potential for the plasma grafting technology in the modification of contact lenses. Comparing to UV-IGP, PECVD can produce a thinner and more uniform coating on the RGP contact lens surface and has lower environmental impact.

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