本論文中利用凱索尼酸與海藻酸鈉進行混摻，成為一種新型水膠。實驗中除了利用流變儀檢視其混和水膠黏彈性，同時亦針對一些基本保水率、細胞相容性以及抗菌性進行分析，評估其對於創傷敷材之應用。
經由實驗數據結果發現，海藻酸-凱索尼酸水膠與鈣離子交聯後大幅提升其材料黏彈性質，機械性質更加穩定。對於水膠膨潤度表現上含有凱索尼酸之水膠，在浸潤時間增長，薄膜開始穩定，相對於純海藻酸鈉水膠具有較佳表現。海藻酸-凱索尼酸水膠在細胞毒性測試可以看出，海藻酸鈉對於纖維母細胞而言是沒有毒性的；然而凱索尼酸濃度大於0.5%對於纖維母細胞並無造成明顯毒性反應，雖影響纖維母細胞之存活率，但L929仍能生長，並未導致全數死亡。於細胞增生測試中亦是呈現有增進細胞增生，而抑菌性結果表示無明顯抑菌性質，顯示本研究之海藻酸-凱索尼酸水膠具有細胞相容性。本研究所製備之濃度比例的海藻酸-凱索尼酸水膠有發展為傷口敷材之潛力。

In this study, chitosonic acid was blended into alginate hydrogel. The mechanical properties of the resulting hydrogels were characterized using rheometer. The swelling behavior and other biocompatibility were also evaluated for the applicability of this hydrogel as a wound dressing. The results showed that after crosslinking with calcium ions, the viscosity, storage modulus and loss modulus of the hydrogel increased with the addition of chitosonic acid. The results of biocompatibility test against L929 fibroblasts showed that the hydrogels were non-toxicity for L929 fibroblasts, although the proliferation was inhibited slightly when the content of chitosonic acid was higher. Overall results demonstrated that alginate-chitosonic acid hydrogel exhibited the potential for wound dressing applications.

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