根據文獻記載，具多孔結構鈦金屬植體相較於平坦表面鈦金屬植體對於短時間細胞貼附及長時間於表面之穩定性均有改善的作用。本研究中，除了於表面製造多孔結構，另於表面塗佈上膠原蛋白/幾丁聚醣複合薄膜；其目的在於膠原蛋白可提供支架結構上之強度、並有加速骨細胞分化之功能，幾丁聚醣可誘導骨組織生長極具凝血及抗菌；並於細胞實驗中(in vitro)探討骨母細胞(osteoblasts)貼覆於鈦金屬植體後，於植體表面之貼附、生長及分生情形；動物實驗(in vivo)則是探討此一經表面改質後之植體植入動物體後，骨組織於植體周遭之骨癒合、新生骨於表面生成情形。期許經此一表面改質後之植體，相較於傳統植體，在加速骨組織於植體周遭再生、癒合的時間、骨整合之程度均有改善的作用，近一步希望此技術能應用於未來之植牙用植體或一般手術用植體，減少患者之痛苦及縮短患部癒合之時間。

According to research, the short-term adhesion and long-term stability on surface of porous structural implants are much better than smooth ones. In this study, the surface were coated collagen/chitosan complex membrane in addition to surface porous structure. Collagen provided scaffold strength and accompanies a function that accelerated the differentiation of osteoblasts. Chitosan with the purpose of guiding bone tissue growth, hemoglutination, and antibacterial. The adhesion, proliferation, differentiation of osteoblasts on titanium implants were tested in vitro; the bone healing and new-bone formation around the implants after implanting the surface-modified Ti plates into animal bodies were discussed in vivo. We expect that the time of bone regeneration , the bone integration and bone healing around implants could be improve by the surface-modification treatment. Moreover, with the purpose that reduced the suffering of patients and shortened the bone healing time, we hope this treatment could be introduced to surgical or dental implants soon after.

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