磷灰石/矽礦石複合β-三鈣磷酸鹽生醫玻璃陶瓷骨替代材之開發

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研究生：	劉榮展 Jung-Chan Liou
論文名稱：	磷灰石/矽礦石複合β-三鈣磷酸鹽生醫玻璃陶瓷骨替代材之開發 Development of apatite/wollastonite and β-TCP glass-ceramic-based bone implants
指導教授：	施劭儒 Shao-Ju Shih
口試委員:	王丞浩 Chen-Hao Wang 陳祥和 Hsiang-Ho Chen 鍾仁傑 Ren-Jei Chung
學位類別：	碩士 Master
系所名稱：	工程學院 - 材料科學與工程系 Department of Materials Science and Engineering
論文出版年：	2016
畢業學年度：	104
語文別：	中文
論文頁數：	116
中文關鍵詞：	A/W 生醫玻璃陶瓷、β-三鈣磷酸鹽、生物活性、降解、噴霧熱解
外文關鍵詞：	A/W glass-ceramic, β-tricalcium phosphate, Bioactivity, Degradation, Spray pyrolysis
相關次數：	點閱：341 下載：2
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自從1982年日本Kokubo團隊等人發明A/W 生醫玻璃陶瓷 (A/W glass-ceramic)後，因為其具有高強度、高硬度等機械性質，且同時擁有良好的生物活性，於臨床上廣泛的被應用於人工脊椎骨、椎間盤以及股骨等方面的修補；然而該材料降解速率極為緩慢，不利於新生骨生成時提供足夠的生長空間。為了彌補A/W 生醫玻璃陶瓷低降解速率的缺點，本研究藉由結合可吸收性生醫陶瓷β-三鈣磷酸鹽與A/W生醫玻璃陶瓷以改善其不足。實驗中以噴霧熱解法製備A/W-CP 生醫玻璃陶瓷前驅粉體，將其製作成塊材後以不同熱處理(700-1100oC)溫度進行燒結，並將燒結後塊材浸泡於模擬人體體液進行體外生物活性測試，發現經由1100 oC熱處理後之A/W-CP生醫玻璃陶瓷具有最佳生物活性，且較商用塊材(Cerabone®A-W) 有較高的降解性。本實驗以X光繞射儀分析熱處理後塊材之相組成，並鑑定生物活性測試後塊材相比例之變化；以掃描式電子顯微鏡觀察磷灰石層於表面生成情形。

The apatite/wollastonite glass-ceramic (A/W GC) was first reported by Kokubo in 1982. It has been widely applied in clinical fields such as artificial vertebrae, disc and femur repairing, because the A/W GC has the advantages of superior bioactivity and excellent mechanical properties. However, for A/W GC there are still some disadvantages, for instance, the degradation rate (almost no degradation) is too slow to provide the space for the new bone generation. In order to overcome the drawbacks of slow degradation rate, this study combined the A/W GC with resorbable bioceramics namely β-tricalcium phosphate (β-TCP) to increase the degradation rate. The apatite/wollastonite/β-TCP glass-ceramic powders were prepared by spray pyrolysis method, and as-prepared bulk samples were sintered under the various sintering temperatures of 700-1100oC. The phase compositions,and morphologies were characterized using X-ray diffraction and scanning electron microscopy, respectively. Also, the degradation rates of A/W-CP GC were measured. In conclusion, 1100 oC sintered A/W-CP　GC sample has the highest bioactivity among samples. Moreover, A/W-CP　GC samples have higher degradation rate than commercial product (Cerabone®AW).

摘要	I
Abstract	IV
致謝	VI
目錄	VII
第一章、	緒論	1
1 前言	1
2 研究動機與目的	2
第二章、文獻回顧	3
1生醫陶瓷簡介	3
1.1 生醫材料之簡介	3
1.2 生醫材料之定義	3
1.3 生醫材料之基本要求	4
1.4 生醫材料之分類	5
1.5 生醫陶瓷之市場需求及種類	7
2 近惰性生醫陶瓷	10
2.1氧化鋁	10
2.2氧化鋯	12
3 可吸收性生醫陶瓷	15
3.1 半水硫酸鈣	16
3.2 磷酸鈣骨水泥	18
4 表面生物活性陶瓷	21
4.1 生物活性之介紹	22
4.2 生物活性鍵結之機制	25
4.3 氫氧基磷灰石 (Hydroxyapatite)	27
4.4生物活性玻璃 (Bioactive glass)	29
4.5 A/W生醫玻璃陶瓷 (A/W glass-ceramic)	33
5 A/W 生醫玻璃陶瓷	33
5.4 A/W 生醫玻璃陶瓷之機械性質	34
5.4 A/W 生醫玻璃陶瓷之合成方法	35
6 三鈣磷酸鹽 (TCP)	36
7 噴霧熱解法介紹	38
7.1 噴霧熱解法之簡介	38
7.2 顆粒成型機制	40
7.3 靜電沉積技術	43
第三章、實驗目的與方法	45
1 實驗設計及其目的	45
2 實驗原料	47
3 實驗儀器設備	48
4 樣品製備之步驟	49
4.1 磷灰石 (Apatite, A)粉體之製備與收集	49
4.2 矽礦石 ( β-Wollastonite, W)粉體之製備與收集	49
4.1 A/W-CP生醫玻璃陶瓷粉體之製備與收集	49
4.2 A/W-CP生醫玻璃陶瓷塊材之製備	50
5體外生物活性評估	51
6降解測試	51
7 粉體與塊材的性質及分析方法	52
7.1 X光繞射儀分析 (X-Ray diffraction analysis, XRD)	52
7.2 場發射掃描式電子顯微鏡 (Field-emission scanning electron microscope, FE-SEM)	56
第四章、實驗結果	58
1 前驅物之熱重分析	58
2磷灰石 (Apatite) 粉體之性質分析	59
2.1 X光繞射分析	59
3 矽礦石 ( β-Wollastonite) 粉體之性質分析	61
3.1 X光繞射分析	61
4 A/W-CP 玻璃陶瓷粉體之性質分析	63
4.1 X光繞射分析	63
4.2場發射掃描式電子顯微鏡分析	64
5 A/W-CP 玻璃陶瓷塊材之性質分析	65
5.1 X光繞射分析	65
5.2場發射掃描式電子顯微鏡分析	67
6 塊材之體外( In vitro)生物活性測試	69
6.1 700°C-sintered samples	70
6.2 800°C-sintered samples	73
6.3 900°C-sintered samples	76
6.4 1000°C-sintered samples	79
6.5 1100°C-sintered samples	82
7  降解測試	85
第五章、討論	86
1 相比例之組成	86
2  700°C-sintered samples	88
3  800°C-sintered samples	89
4  900°C-sintered samples	92
5  1000°C-sintered samples	93
6  1100°C-sintered samples	95
7  生物活性探討	97
8  pH 值變化	99
9  降解行為	100
第六章、結論	102
第七章、未來工作	103
參考文獻	104

                                

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