本研究將以矽酮類高分子(silicone)作為隱形眼鏡基材，開發具有抗蛋白沉積、抗菌性、親水性佳、高舒適性的多功能矽水膠隱形眼鏡，以達到長時間配戴及配戴舒適性的效果。隱形眼鏡每日貼附在角膜上，空氣中或雙手上的微生物均有機會因鏡片清潔不足而入侵眼睛，使眼角膜發炎、疼痛等受損情況。因此，隱形眼鏡需具有抗菌性的功能，來維持眼睛的健康。眼睛乾澀為目前配戴隱形眼鏡最常面臨的問題，伴隨著鏡片上的沉澱物(淚液的蛋白質和脂質)，而造成視覺對比度的下降，都會使配戴起來不舒適而減少配戴時間。因此，隱形眼鏡也須具備抗蛋白沉積功能，以增加配戴者的舒適度。
本研究使用聚二甲基矽氧烷(PDMS)為基材，利用電漿活化表面，使表面產生過氧化物，而後接枝上丙烯酸單體(acrylic acid)，再利用丙烯酸的羧基(-COOH)使之與幾丁聚醣(chitosan, CS)氫氧基(-OH)形成共價鍵結，完成固定幾丁聚醣程序。最後再經戊二醛交聯反應，結合上透明質酸(hyaluronic acid, HA)完成表面改質。以DPPH過氧化基分析和表面接枝密度量測，結果顯示出幾丁聚醣與透明質酸成功接枝於表面上且經原子力顯微鏡量測表面粗糙度，粗糙度值下降。親水性方面，接觸角有明顯降低，表面親水性有明顯提升。利用BCA蛋白質測定，可得知因透明質酸結構能抵抗蛋白質沾附，使得蛋白質吸附下降。細胞毒性經ISO 10993-5判斷為無毒性。抗菌性試驗中可發現幾丁聚醣對於金黃色葡萄球菌和大腸桿菌，具有優異的抗菌效果。

This study is about modification of silicone hydrogel contact lenses. The resultant contact lenses exhibited anti-bacterial activity, anti-adhesion of proteins and high hydrophilicity. Our goal is to create more comfortable and longer-term contact lenses.
Antibacterial activity and anti-protein deposition are the most important consideration in the contact lenses. People use contact lenses by touching the contact lenses with their finger. This contact may contaminate contact lenses and lead to inflammation and pain on the cornea. Therefore, anti-bacterial activity is needed to prevent pathogenic problems.
Anti-protein deposition is needed to prolong the wearing time of contact lenses. Deposition of proteins and lipids will reduce visual contrast. It was one of the reason contact lenses is uncomfortable to wear.
To meet our goal, chitosan (CS) and hyaluronic acid (HA) will be covalently bonded to the surface of the contact lenses (PDMS-CS-HA). According to these ways, we can enable to inhibiting bacteria growth and protein deposition on the contact lenses surface. However, the optical transparency, water content, oxygen permeability, tensile strength and modulus will not significantly change.
The overall results demonstrated that new modification of contact lenses has a good potential in the application of ophthalmic lenses

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