原油為不可再生之資源，隨著全球經濟發展，原油需求量不斷上升。為了永續發展之目的，各種新型態的化工製程因應而生。本研究嘗試結合反應器與萃取塔，達到總能耗下降及降低年總成本之目的。
研究上，以異丁烯加水產生叔丁醇之水合反應為範例，進行反應萃取程序之模擬並與反應蒸餾程序比較。於反應萃取程序中，考量進料中可能含有正丁烯，也同時進行含正丁烯之反應萃取程序之模擬。穩態模擬結果顯示，反應萃取程序在不需要提供能源的條件即可達到高轉化率，但受限於液液相平衡，分離段中需要較多之成本。整體而言，反應萃取程序於節能與減少年總成本方面皆有較好之表現，分別可以節省 26.0 %及16.1 %。
於動態模擬中，利用含正丁烯之反應萃取程序設計控制架構。不同於一般萃取塔，反應萃取塔包含化學反應與液液分相，因此於庫存控制環路中提出三種控制架構 (Inventory A~ C)，針對化學計量平衡、液液相平衡與考慮兩者之情況進行討論。於品質控制環路中，由於單點溫度控制於C1蒸餾塔無法有效的排除擾動，利用雙點溫度控制則可以改善動態擾動之結果。結果顯示利用雙點溫度控制搭配Inventory C 為本研究最佳的控制架構。

Crude oil is a non-renewable resource, The demand of crude oil continuously increases, as the global economic development. For the purpose of sustainable development and minimize production costs of the chemical industry, different types of chemical processes are developed. This study attempts to combine the reactor and the extraction process to reduce energy consumption and total annual cost.
In the research, the reactive extraction in hydration of tert-butyl alcohol is demonstrated and compared with reactive distillation. The feed may contain impurity, like n-butene, so reactive extraction with n-butene is also demonstrated. The reactive extraction can achieve high conversion without energy. In constrain of liquid-liquid equilibrium, the higher cost of the separation section is required. The steady state simulation result shows the reaction extraction can save 26.0 % energy consumption and 16.1 % total annual cost, respectively.
In process dynamics, the reactive extraction with n-butene is used to demonstrate. Since the reactive extraction column contains chemical reaction and liquid-liquid separation. Three inventory control loops (Inventory A~C) are studied to maintain stoicmetric balance, liquid-liquid equilibrium and both situations. In the quality control loop, using two temperature control loop in column C1 is better than one temperature control loop. The dynamic result shows that the best control structure is two temperature control loop in column C1 with inventory C.

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