蒸餾裝置啟動(startup)的動態操作包含了大量的熱量傳遞與質量傳遞的操作控制，以及大範圍的操作條件，實為化學工業中極為複雜的動態操作之一。由於蒸餾塔啟動中，為了達到常態操作所消耗的時間與能量非常可觀，且在啟動過程中的產物大都不合規格，因此降低啟動過程中達到常態操作所需的時間甚是重要。本研究提出了兩種反應蒸餾啟動程序的最適化過程: 醋酸甲酯以及醋酸丁酯，並探討此兩種程序的啟動方法及最佳初始進料啟動策略。
不同於普通蒸餾啟動程序，此兩種程序在反應蒸餾塔將會有兩股反應物進料。此外，由於反應在蒸餾塔的反應段進行，因此，初始注入策略將是縮短啟動時間的一個重要操作。於本研究中，四到五個初始注入策略將會結合模擬退火法被使用在此兩種反應蒸餾程序上，進而找出最短的啟動時間。
結果顯示，醋酸甲酯反應蒸餾程序的最佳初始注入策略為先填充塔頂產物於迴流罐，與塔底同時將等莫耳的兩反應物填入凝液罐，加上搭配採用模擬退火法取得之再沸器升溫策略，可使塔頂較早達到穩態，使得啟動時間減少，相較於僅在塔底凝液罐初始注入雙反應物的策略，減少了約8.91小時的啟動時間，總能耗量則是11.5 GJ。而醋酸丁酯反應蒸餾程序的最佳初始注入策略亦類似於醋酸甲酯反應蒸餾程序，雖然其啟動時間約增加了0.48小時，總能耗量為83.26 GJ，但使用模擬退火法尋找最佳再沸器加熱量路徑使得啟動過程中的塔底凝液罐之液位較容易被控制住。

The startup of a distillation column involves the control of complex heat and mass transfer operations, and a wide range of operating conditions, represents one of the most complicated dynamic operations in the chemical industry. The startup procedure is time and energy consuming and the process is unproductive during this transient period before the steady state. It is desirable to reduce the transient period and consequently the startup time. This work proposes the optimization of startup for two kinds of reactive distillation (RD) processes: methyl acetate and butyl acetate. With these two processes, different startup procedures and optimal initial charge policies have been investigated in this research.
Unlike the startup of a conventional distillation, two reactants will feed into the RD column. Furthermore, reaction will take place in the reactive zone. Therefore, the initial charge policy will be an important operation to shorten the startup period. In this research, there are four to five initial charge policies would be considered to find the shortest startup period by using simulated annealing approach for each processes. Results show that combination of simulated annealing approach (SA) and dynamic simulation, the best initial charge policy of methyl acetate process is methyl acetate charging into reflux drum and feed both reactants into sump first. Because top of the column earlier reach steady state. Furthermore, the optimal startup time period can be shortened 8.91 h than the case we feed both reactants into column in the same time. And the total energy requirement is 11.5 GJ. The result of butyl acetate process quite similar even it contains additional decanter. The best initial charge policy of this process is water charging into reflux drum and feed both reactants into sump first. Although its startup time increase approximately 0.48 hours, total energy requirement increase approximately 1.8 %, but entire startup process can be improved significantly by using SA to find the optimal reboiler duty increase path.

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