第一部分
本研究以溶劑熱法控制合成Ag2S反應晶種，並透過不同二次金屬在其表面沉積成長或是進行陽離子交換，獲得組成、形狀以及材料特性大不相同異質結構奈米晶體，如.Ag2S-ZnS、Ag2S/CdS、Ag2S/CdS-ZnS、Ag/AgInS2奈米晶體。不同於其他金屬晶種，Ag+離子在Ag2S晶種中就像是流體一般表現出高度的流動性，使得Ag2S晶種表面產生大量的陽離子缺陷位置，適合做為異質結構成長之晶種，即使是在晶格不匹配度相當大的界面上，仍然可以維持高度的穩定性。目前本系統已經能夠合成球型、三角形、棒子等不同形狀之奈米晶體，並藉由反應時間與二次金屬反應濃度控制奈米晶體尺寸大小，最後我們藉由穿透式電子顯微鏡、X光繞射圖譜、能量散佈能譜儀、X射線光電子能譜儀、螢光光譜儀、UV-vis吸收光譜儀以及循環伏安法等，對我們所合成之異質結構材料進行分析和鑑定。
第二部分
本研究目的將建立在生醫分子影像的基礎上，進行Methotrexate抗癌藥物偶聯AgInS2/ZnS量子點，由於研究所用之AgInS2/ZnS量子點屬於有機相，致使量子點無法溶於水溶液相，當量子點應用於生物系統時，必須在量子點進行表面修飾和官能基的改質，因此我們將以兩性高分子的包覆，使其表面具有大量親水性羧基轉為極性相之AgInS2/ZnS量子點，最後利用EDC/NHS共價偶聯系統將量子點與甲氨蝶呤(Methotrexate、MTX)抗癌藥物結合在一起，開發出一個兼具細胞螢光顯影、藥物標靶以及藥物治療等多功能性量子點，期待未來在醫學臨床上有更廣泛之應用。

Part I
In this study, we synthesized Ag2S as crystalline seeds through thermal deposition, then further deposited different secondary metal or cation exchanging on the surfaces of Ag2S to obtain heterostructure nanocrystals with various types of compositions, shapes and properties, such as Ag2S-ZnS, Ag2S/CdS, Ag2S/CdS-ZnS and Ag/AgInS2. Unlike other metal seeds, Ag+ showed a fluid-like characteristic and exhibited high degree of mobility in the Ag2S, leading to more defects of cation. Even in large lattice mismatch at the interface, the growth of heterostuctures benefited from those defects. By controlling the reaction time and the concentration of secondary metal, we were able to synthesize spherical, triangular and stick nanocrystals. Finally, the heterostructure materials were identified by transmission electron microscopy, X-ray diffraction patterns, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, fluorescence spectroscopy, UV/vis absorption spectroscopy and cyclic voltammetry.
Part II
In this research, we investigated the Methotrexate (MTX) anticancer drugs conjugating with the AgInS2/ZnS quantum dots. The AgInS2/ZnS quantum dots cannot dissolve in aqueous phase. For biological application, PMAO were linked to the surfaces of AgInS2/ZnS quantum dots to make AgInS2/ZnS quantum dots dissolve in aqueous phase. Subsequently, the MTX anticancer drugs conjugated with the modified AgInS2/ZnS quantum dots by straightforward EDC/NHS catalyzed coupling reaction in order to develop multifunctional quantum dots including cell imaging, targeting and drug therapy.

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