本研究使用全民健康保險局研究數據資料庫，資料範圍涵蓋1995至2010年，包括台灣2千3百萬居民的住院和門診醫療紀錄。本研究調查癌症轉移的發病率，開發癌症轉移的馬可夫鏈模型，提供國家五年癌症防治計畫前、中、後癌症發病與轉移機率的分布。

This study uses the data from the Taiwan National Health Insurance (NHI) research database between 1995 and 2010. NHI is a national database containing inpatient and outpatient medical benefit claims for Taiwan's 23 million residents. This study uses NHI to investigate the incidence of cancers metastasis. We develop a Markov chain model for 36 major cancers and their metastasis behavior, which offers a probabilistic description of the time-history of the diseases as it unfolds through the metastatic cascade.

Arnold M., Razum O., Coebergh J.W., 2010, Cancer risk diversity in non-western migrants to Europe: An overview of the literature, European Journal Cancer, 46(14), 2647-2659.
Broyles J.R., Cochran J.K., Montgomery D.C., 2010, A statistical Markov chain approximation of transient hospital inpatient inventory, European Journal of Operational Research, 207(3), 1645-1657.
Eslahchi C., Movahedi F., 2011, Calculation of transition probabilities in the birth and death Markov process in the epidemic model, Mathematical and Computer Modelling, 55(3-4), 810-815.
Gana X., Duanmub J., Congb W., Wangc M., 2011, Research on Flight Mishap 10000-Hour-Rate Prediction Method Based on Markov Chain, Energy Procedia, 11, 5023-5027.
Golub G.H., Van Loan C.F., 1996, Matrix Computations, Johns Hopkins U. Press.
Gonzalez C.A., Riboli E., 2010, Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, European Journal Cancer, 46(14), 2555-2562.
Andrew Greasley.A, 2004, Simulation Modelling for Business, Ashgate Publishing Ltd., pp. 79.
Heins M.J., Korevaar J.C., Rijken P.M., Schellevis F.G., 2012, For which health problems do cancer survivors visit their General Practitioner, European Journal Cancer, 49(1), 211-218.
Linden W., Vodermaier A., MacKenzie R., Greig D., 2012, Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and age, Journal of Affective Disorders, 141(2-3), 343-51.
National Health Insurance Research Database, 2012, The data protection, http://nhird.nhri.org.tw/en/Data_Protection.html.
National Health Research Insurance, 2012, The NHRI research introduction, http://english.nhri.org.tw/NHRI_WEB/nhriw001Action.do?status=Show_Data&uid=20110614216839910000.
Nguyen D.X., Massague J., 2007, Genetic determinants of cancer metastasis, Nature Reviews Genetics, 8(5), 341-52.
Norris J.R., 1998, Markov chains, Cambridge University Press.
So M.M.C., Thomas L.C., 2011, Modelling the profitability of credit cards by Markov decision processes, European Journal of Operational Research, 212(1), 123-130.
Wang L., Liang H., Wang X., Li F., Ding X., Deng J., 2010, Risk factors for metastasis to para-aortic lymph nodes in gastric cancer: A single institution study in China, Journal of Surgical Research, 179(1), 54-9.
Yaesoubi R., Cohen T., 2011, Generalized Markov models of infectious disease spread: A novel framework for developing dynamic health policies, European Journal of Operational Research, 215(3), 679-687.