One of the visions of Industry 5.0 is a human-centered design and value creation. In the quality field, the Lean Six Sigma (LSS) method has been proven to develop better production activities successfully. Embedding LSS into a human-oriented discipline can create a perfect combination of more human processes and a better result environment. The Lean concept adopts a people-oriented approach, cares about employees and customers, and emphasizes sustainable development. At the same time, Six Sigma philosophy and Industry 5.0 emphasize innovation to reduce process variation and achieve iterative process improvement. This study proposes a new sustainable innovation framework (SIF) through inductive and integrative approaches based on LSS methodology and Industry 5.0 technologies to achieve process excellence. Three Lean 5.0 tools, RIDEM (Requirements, Initiation, Design, Execution, and Monitoring) approach, and LSS 5.0 implementation steps are developed. These novel tools are designed to support the concept of actual SIF becoming more implementable. A case study has been conducted to illustrate how LSS 5.0 tools can be applied and their implementation results. The number of defective parts per million (DPPM) has been greatly reduced by more than 80%, directly saving NT$104,000. This study can make a significant contribution through the proposed framework, and the practical concepts are easier to implement in work organization.

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