本研究以固定床反應器探討戊二酸與甲醇的非均相酯化反應動力行為，以酸性陽離子交換樹脂Amberlyst 35為觸媒，實驗操作於313.15 K ~ 333.15 K之間，進料醇/酸莫耳比為15和20。實驗結果顯示戊二酸的反應速率隨溫度增加而提高，但在本實驗之溫度範圍內的平衡轉化率皆很接近，亦即此一酯化反應的熱效應非常小，因此整個觸媒顆粒內部可視為進行恆溫反應。另外，當進料莫耳比增大時，平衡轉化率些微提高。實驗的結果也顯示在較長滯留時間下，可忽略質傳阻力的存在。
　　本研究分別以三種理想溶液擬均相動力模式關聯所量取之動力數據，以求得模式中的動力參數值。關聯的結果顯示動力模式三為最適合描述戊二酸與甲醇之酯化反應動力行為，此一模式將可提供後續戊二酸二甲酯合成之反應性蒸餾系統的模擬與設計使用。

The kinetic behavior of heterogeneous esterification of glutaric acid with methanol over an acidic cation-exchange resin, Amberlyst 35, was investigated with a fixed-bed reactor. The esterification was performed at temperatures between 313.15 K to 333.15 K and the molar ratios of feed (methanol to adipic acid) at 15 and 20, respectively. The reaction rate was found to increase with increasing temperature, but the equilibrium conversions of glutaric acid were close over the entire range of experimental conditions. It means that the heat effect is minor and thus the reaction can be assumed as isothermal within the catalyst beads. It was also found that the equilibrium conversion of glutaric acid increases slightly as the molar ratios of feed increasing from 15 to 20. The experimental results showed that the transport resistance could be neglected while the residence times were long enough.
　　The kinetic data were correlated with three different ideal solution quasi-homogeneous kinetic models. The model parameters were determined by fitting the kinetic data to these models. The third model yielded the best representation for the kinetic behavior of esterification of glutaric acid with methanol. This model can be applied to the process simulation and design for production of dimethyl glutarate via reactive distillation.

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