人眼的視網膜上分布著大量的微血管，藉由觀察眼底的視網膜，不只能發現眼睛疾病的狀況，也可以為人體許多其他器官病變提供早期診斷的方式，如糖尿病、高血壓、心臟病等疾病。在眾多的醫學檢測方式中，視網膜攝影為目前唯一可以採用非侵入式觀察微血管的檢測技術，具有安全、衛生、快速及可重複使用等特性。隨著智慧型手機的普及以及現代人對身體健康及預防醫療的重視，研發製作基於智慧型手機的可攜式眼底相機不僅能讓個人及時監控身體狀況，亦有利於將眼底檢查推廣至落後及偏遠地區，具有十分重要的意義。
因此，本文基於手機相機提出一種照明與成像光路結合的眼底相機架構，利用光路可逆的概念，設計可同時滿足成像及照明所需之透鏡組，且兼具小體積、少元件、高可攜性之特性。本研究進一步加入偏振光學元件，降低針對眼球角膜及光學元件的介面反射光所造成的雜散光對成像品質的影響，並利用低色溫光源增強眼底影像能量。本研究的最終設計結果顯示：在眼底觀測範圍為45度視角時，眼底照明均勻度大於90%，雜散光能量小於總能量6%，其物方最高分辨率可達7微米。

The retina of the human eye is distributed with large numbers of microvessels. By the retinal detection, we can obtain the state of the eye disease and the information used for early diagnosis of many other organ diseases such as diabetes, hypertension, heart disease and so on. In many therapeutic methods, retinal photography is one of the non-invasive observation technology of microvascular detection, with safety, health, rapid and reusable. With the popularity of smartphones and the attention of health and preventive care, development of smartphone-based camera can allow individuals to monitor the physical condition promptly and helps the promotion of retinal examination and medical rescue in the backward country and remote areas.
Therefore, a fundus camera architecture based on the smartphone camera which combined of lighting and imaging optical path is proposed by this research. By the reversible of the optical path, we designed the lens group to meet the imaging and illumination requirements and kept the system in small size to reach excellent portability. In this study, the polarizing optical element was further added to reduce the effect of stray light composed of the interfacial reflected light from the cornea and the optical elements, and enhance the signal to noise ratio of fundus image by using a low color temperature light source. The final results of this study show that the fundus illumination uniformity is greater than 90% when the fundus observation range is 45 degrees, the stray light energy is less than 6% of the total energy, and the highest resolution of the object is 7 microns.

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