近年來生醫金屬植入材常使用鐵、鈦、與鈷系合金材料為大宗，因其具有高硬度、高彈性模數等物理性質，同時具備生物惰性之優勢。然而，當此類金屬材料植入體內後，容易在界面處誘發炎症因子，進而引發異物反應和排斥作用，導致傷口無法有效癒合，使得成效不彰。此外，此類生醫金屬植入材在體內長時間會受到體液腐蝕，並釋放金屬離子於體內循環系統，而有引發慢性病之疑慮。
為改善上述金屬植入材之缺陷，現今相關研究多以氫氧基磷灰石塗層進行表面改質，並由於其良好的骨傳導和生物活性特性，是牙科和骨科的首選生物材料。然而相較於生物活性玻璃塗層，氫氧基磷灰石形成速率較慢、且因其結晶結構易造成與鈦的粘附性下降。
為拓展新的植入物塗層，本研究以表面改質方式，使用磁控濺鍍製程，披覆生物活性玻璃薄膜於金屬植入材表面，以提升其生物相容性，且提供額外地生物活性與生物功能性。此外，本研究將以噴霧乾燥法製備濺鍍靶材所需之生物活性玻璃粉體，該製程具有生產快速、成分均勻及化學可調性等優勢，並且透過冷壓工法與高溫燒結方式完成靶材製作。最後，所製備之粉體及薄膜將將藉由掃描式電子顯微鏡、能量色散光譜及傅立葉轉換紅外線光譜等手法，針對其物性與化性進行分析及探討。此外，材料之生物活性將及骨傳導性亦將以體外試驗進行評估。

In recent years, iron, titanium, and cobalt-based alloys have been commonly used as biomedical metal implant materials due to their high hardness, high elasticity modulus, and bioinert. However, after implantation, these metal materials can easily induce inflammatory factors at the interface, leading to foreign body reactions and rejection, which impairs effective wound healing. In addition, these biomedical metal implants can be corroded by body fluids over time and release metal ions into the circulatory system, raising concerns about chronic diseases.
To overcome these defects of metal implants, current research focuses on surface modification using hydroxyapatite coatings. Due to its excellent bone conduction and biocompatibility, hydroxyapatite is a preferred biomaterial for dental and orthopedic applications. However, compared to bioactive glass coatings, hydroxyapatite has a slower formation rate and can cause a decrease in adhesion to titanium due to its crystalline structure.
To expand the scope of implant coatings, this study uses magnetron sputtering to deposit a thin film of bioactive glass on the surface of metal implants through surface modification, to enhance their biocompatibility and provide additional bioactivity and biological functionality. In addition, this study will prepare bioactive glass powder required for sputtering targets using spray-drying, which offers advantages such as rapid production, uniform composition, and chemical adjustability. The target will be produced using cold pressing and high-temperature sintering. Finally, the properties and characteristics of the prepared powder and films will be analyzed and explored through scanning electron microscopy, energy dispersive spectroscopy, and Fourier-transform infrared spectroscopy. Furthermore, the biocompatibility and bone conduction of the materials will be evaluated through in vitro experiments.

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