磁共振頻譜(MRS)提供一種非侵入性的方式來量測大腦內代謝物濃度含量的變化。而功能性磁共振頻譜(fMRS)則是針對大腦接受刺激時(視覺、觸覺…等)腦中代謝物濃度的變化。近幾年的研究指出，在7T磁場強度的MRI儀器下進行視覺刺激的fMRS實驗，代謝物會有顯著的變化。在這些研究中發現，Glu以及Lac在接受視覺刺激時，分別增加了2%以及17%。我們認為在3T磁場強度下的儀器進行fMRS實驗，也有機會可以觀察到代謝物的濃度變化。我們選定卓別林的喜劇電影當作視覺刺激的材料，觀察區域為視覺區，實驗的內容主要是由兩段從影片中剪輯出來的片段中間穿插休息時間所組成，比較影片播放區間以及未播放區間的變化。初步的結果表明，代謝物的濃度在接受視覺刺激時沒有發現顯著的變化，但經過更進一步的分析後我認為，如果調整、更換實驗的第二段影片，仍然有機會在3T的系統下觀察到fMRS的濃度變化。

Functional magnetic resonance spectroscopy of brain has been used to study brain metabolism during activation. Recent studies have reported metabolic change during visual and motor stimuli using MRS at 7 Tesla MRI system. In these studies, glutamate (Glu) and lactate (Lac) have been found to increase by 2% and 17% during stimuli using block design in fMRS experiments. We think there is potential to perform fMRS experiments at 3 Tesla system. Chaplin’s comedy movies were selected as stimuli material and voxel is located at visual cortex. Visual stimuli were given with block design consisting of 1 baseline section, 2 black-white movie clips sections and 2 rest sections. Our preliminary results showed that concentration of metabolites do not have significant change. But in further analysis show that it still has chance to find the concentration change using fMRS in 3 Tesla system if experiment is adjusted.

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