介孔生物活性玻璃(MBGs) 近年來被廣泛應用於骨植入物、藥物載體以及補牙骨粉等。前人研究指出：化學組成及比表面積為影響生物活性玻璃的生物活性之兩大因素；而此二者可分別由調整矽(Si) 與鈣(Ca) 的比例以及改變顆粒形貌來提升其生物活性。此外，使用介面活性劑為模板可製備出介孔結構進而增加比表面積。本研究藉由改變SiO2-CaO-P2O5成分比及添加不同種類之介面活性劑，使用噴霧熱解法成功合成出介孔生物活性玻璃 (MBGs)。此研究致力於探討不同化學組成以及介面活性劑種類對MBG生物活性的影響。將製備後的粉體浸泡於模擬人體體液(SBF) 中，測試其生物活性。利用X光繞射儀(XRD)、傅立葉轉換紅外線光譜儀(FTIR) 、掃描式電子顯微鏡(SEM)、穿透式電子顯微鏡(TEM)、氮氣吸/脫附分析儀(BET) 分別來鑑定相變化、化學鍵結、表面形貌、內部結構及比表面積。本研究中發現介孔顆粒有球形及皺摺形兩種形貌。58S 、68S 和 76S MBG 粉體浸泡於SBF 中12 小時內即可生成氫氧基磷灰石(HA)；反之85S浸泡三天後亦無任何氫氧基磷灰石生成。藉由分析氫氧基磷灰石的峰值強度可推斷出：使用任一種介面活性劑製備MBG，其生物活性皆為68S> 58S> 76S> 85S；而在相同成分下，使用不同種類介面活性劑製備出MBG的生物活性則為L121系MBGs > F127系MBGs > P123系MBGs。

Mesoporous bioactive glasses (MBGs) have recently been applied to numerous applications such as bone implants, drug carriers and tooth repairing pastes. Previous studies indicate that the chemical composition and surface area of MBGs are two important parameters which influence the bioactivity of bioactive glasses. Controlling the chemical composition and surface area by modifying the ratio of Si:Ca and particle morphology are necessary in order to achieve high bioactivity. In addition, surfactants as a role template in the preparation of bioactive glasses created the mesoporous structure and increased the surface area. MBGs with various compositions of SiO2-CaO-P2O5 and different surfactant types have been successfully synthesized using spray pyrolysis technique. In this study, the effects of different chemical composition and surfactant type on the bioactivity of MBG samples were studied. Simulated body fluid (SBF) was used as a medium to conduct the bioactivity test with different immersing times. Various characterization methods, including X-ray diffraction analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and Brunaeur-Emmet-Teller method have been used to characterize the phase compositions, chemical bonding, surface morphologies, inner structures, and surface area, respectively. In summary, spherical and wrinkled mesoporous particle shapes were observed. 58S, 68S and 76S MBG powders have the ability to form apatite phase within 12h of immersion time; however all 85S MBG powders show no apatite phase even after 3 days immersed in the SBF solution. Hydroxyl apatite peak area intensity analysis indicate that the bioactivity order of MBGs prepared using all surfactant types is 68S>58S>76S>85S. From the surfactant aspect, the bioactivity order for all MBG compositions is L121-treated MBGs>F127-treated MBGs>P123-treated-MBGs. Larger pore size in the L121-treated MBGs induces faster HA formation rate.

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