糖尿病高居國人十大死因第五名，原因是糖尿病患者的血糖長時間處在高濃度，除了會使血液黏滯度上升導致血管阻塞及硬化，物質的相互作用也因濃度失衡而出現異常，因此產生許多血管病變。本研究運用雷射都卜勒血流計與心電圖，希望能得知人體在口服葡萄糖耐受性測試(Oral Glucose Tolerance test-OGTT)過程中，血管狀態與局部血流的變化，透過統計與分析的結果進而預測糖尿病的發生。
量測方式是在右手與右腳等部位量測體表的血流訊號，透過血流訊號在頻域與時域分析的結果，觀察受測者以血糖由高至低分成的「糖尿病患者」、「血糖過高但不達糖尿病標準者」、「非糖尿病患者」三組之間的差別。
從量測方式與分析結果可得知長時間處於高血糖的A組，內皮細胞活性、交感神經作用與血管平滑肌功能可能受損，血流阻力與血管堵塞的情況也可能比血糖較正常的B、C組嚴重。短時間的血糖波動對整體而言雖無顯著影響，但數據結果解釋了組織器官受血糖升高時的反應方式。B組數據走勢與A組相似，這代表組織器官在確定罹患糖尿病前就會受到血糖濃度提升而有一定程度的受損，因此在未發生糖尿病前，本研究即可提早偵測到血流效應與血管特性的變化。
從成果可了解血糖對人體有相當的傷害性，也能從數據走向得知糖尿病前期的相關症狀，未來如能從數據趨勢預測受測者是否會罹患糖尿病，即能做到早期預知早期治療，節省醫療資源與減少病患的痛苦。

Diabetes is the fifth leading cause of death in Taiwan, mainly because the glycemia of diabetic always maintained with high level. This phenomenon not only raises the viscosity of blood flow but also make the interchange efficiency of blood substance getting lower, which may further result in many vascular lesions. In this study, we aim to understand the physiological changes of subject during the Oral Glucose Tolerance Test (OGTT). We apply the non-invasive instrument to measure the blood signal of subject’ extremities and analyze the signal with the following two forms: frequency-domain and time-domain. We divided the subjects into three groups, the subject with Diabetes is called A group, the subject with high glycemia is called B group, the subject with normal glycemia is called C group.
From the result, we noted that the endothelial function, neurogenic activity and myogenic activity of A group can be injured. In addition, the vascular occlusion
and blood flow resistance of A group can be worse than B group and C group. The result also could explain the reaction of short-term glycemia fluctuation. According to the present finding we can detect the changes of blood flow and vascular characteristics before getting Diabetes.
In conclusion, we understand the hyperglycemia has significant damage on microcirculatory blood flow supply, and we also could get more information during pre-Diabetes stage.

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