研究生: |
林祐真 You-Zhen Lin |
---|---|
論文名稱: |
聚乳酸與甲基丙烯酸-2-羥基乙酯之半互穿型網狀高分子作為藥物釋放型神經導管的製備 Preparation of semi-interpenetrating network of polylactide and poly(hydroxyethyl methacrylate) for drug releasing-nerve conduit |
指導教授: |
楊銘乾
Ming-Chien Yang 劉定宇 Ting-Yu Liu |
口試委員: |
楊銘乾
Ming-Chien Yang 劉定宇 Ting-Yu Liu 鄭詠馨 Yung-Hsin Cheng |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 材料科學與工程系 Department of Materials Science and Engineering |
論文出版年: | 2022 |
畢業學年度: | 110 |
語文別: | 中文 |
論文頁數: | 88 |
中文關鍵詞: | 神經導管 、半互穿網狀高分子結構 、HEMA 、PLA 、生物相容性 、藥物釋放 |
外文關鍵詞: | nerve conduit, semi-interpenetrating network polymer, HEMA, PLA, biocompatibility, drug release |
相關次數: | 點閱:376 下載:12 |
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本研究旨在設計具有藥物釋放功能之高分子材料,以便作為神經導管。研究方法係將甲基丙烯酸-2-羥基乙酯(HEMA)與聚乳酸(PLA)溶於N-甲基吡咯烷酮(NMP),並加入交聯劑乙二醇二甲基丙烯酸酯(EGDMA)及光起始劑2-羥基-2-甲基-1-苯基-1-丙酮(PI-1173),再以紫外光照射,使HEMA與PLA形成半互穿網狀高分子結構(semi-interpenetrating network, SIPN)。再將SIPN浸入維他命B12 (Cobalamin)之溶液中,吸收藥物。藉由不同比例的HEMA與PLA,探討其機械性質,以及包覆維他命B12後之生物相容性質。研究結果顯示出,此SIPN混合物有良好的生物相容性與機械性質。除此之外,吸收藥物後的SIPN有著較高的蛋白質吸附。因此,本論文所研究之包覆維他命B12的HEMA/PLA之SIPN具有製作神經導管的開發潛力。
In this study, a semi-interpenetrating network (SIPN) polymer was synthesized for nerve conduits with drug delivery functionality. This SIPN was synthesized by polymerizing 2-hydroxyethyl methacrylate (HEMA) in polylactic acid (PLA) dissolved in N-methylpyrrolidone (NMP) using ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent and 2-hydroxy-2-methyl-1-phenyl-1-propanone (PI-1173) as the photoinitiator. After curing with ultraviolet light, the mechanical properties and biocompatibility of the resultant SIPN were evaluated. Furthermore, the SIPN was loaded with vitamin B12 (cobalamin) to investigate the drug release behavior. The results show that this SIPN exhibited suitable biocompatibility and mechanical properties. In addition, this vitamin B12 loading SIPN showed higher protein adsorption. Therefore, these HEMA/PLA SIPN polymers will be promising for making drug-delivery nerve conduit.
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