本研究使用批式反應器探討羥基己酸及戊酸與甲醇進行酯化反應的非均相反應動力行為，反應中使用酸性陽離子交換樹脂Amberlyst 35與Amberlyst 36為觸媒。實驗操作於40 ℃到60 ℃之間，並改變觸媒添加量及不同醇酸進料莫耳比。
酯化反應實驗結果顯示反應速率與酸之平衡轉化率會隨著觸媒量、反應溫度、醇酸進料莫耳比的增加而增加。反應物質間之相對吸附強度由吸附實驗之結果求得，各成分在Amberlyst 35之吸附強弱依序為水 > 甲醇 > 戊酸 > 戊酸甲酯。
羥基己酸甲酯合成反應之動力數據可用理想溶液擬均相模式準確關聯，動力模式參數值經由此數據擬合求得。戊酸與甲醇之酯化反應動力數據分別以理想溶液擬均相模式(IQH)、非理想溶液擬均相動力模式(NIQH)、Langmuir-Hinshelwood-Hougen-Waston (LHHW)模式、Eley-Rideal (ER)模式關聯，NRTL模式用於計算各反應成分之活性係數，關聯的結果顯示LHHW模式為最適合描述戊酸甲酯合成反應的非均相催化動力行為。

The kinetics of the esterification reactions of 6-hydroxycaproic acid or valeric acid with methanol over the cation-exchange resins, Amberlyst 35 and Amberlyat 36, was investigated with a batch reactor. The experiments were conducted at different levels of catalyst loadings and molar ratios of methanol to acid in a temperature range of 40 to 60 ℃.
The reaction rate and the equilibrium conversion of acid increased with increase of catalyst loading, reaction temperature and molar ratio of methanol to acid. The relative adsorption strengths for the reacting species were determined by adsorption experiments. The results indicated that the magnitude of adsorption strengths on Amberlyst 35 followed the order of water > methanol > valeric acid > methyl valerate.
The kinetic data of methyl hydroxycaproate synthesis were correlated well with the ideal-quasi-homogeneous model and the kinetic parameters were determined from the data fitting. The kinetic data of esterification of valeric acid with methanol were correlated with the ideal-quasi-homogeneous (IQH), the non-ideal-quasi-homogeneous (NIQH), the Eley-Rideal (ER), and the Langmuir-Hinshelwood- Hougen-Waston (LHHW) models, respectively. The NRTL model was used to calculate the activity coefficients for each reacting species. The LHHW model yielded the best representation for the kinetic behavior of heterogeneous catalytic synthesis of methyl valerate.

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