本研究的目標是使用一套半流動式裝置，分別量測促進尿酸排泄類藥物(丙磺舒及黃口比酮)與第二代磺醯脲類藥物(格列本脲)在超臨界二氧化碳中的平衡溶解度，溫度範圍為313.2 K~353.2 K，壓力在15 MPa~31 MPa之間。為了確保平衡釜出口之物流已達平衡，各藥品所需的最少接觸時間分別為丙磺舒1500 s，黃口比酮750 s，格列本脲1000 s。在實驗條件範圍內丙磺舒平衡溶解度介於0.13 × 10-5 ~ 1.45 × 10-5，黃口比酮平衡溶解度介於0.29 × 10-5 ~ 2.21 × 10-5，格列本脲平衡溶解度介於0.065 × 10-5 ~ 1.64 × 10-5。實驗所得的溶解度數據以兩種與密度相關之半經驗式(Chrastil模式及Mendez-Santiago-Teja模式)關聯。此兩種模式之計算誤差與實驗不確定度相近。本研究也採用Peng-Robinson狀態方程式結合雙變數vdW混合律進行溶解度數據迴歸，關聯結果尚稱合理，惟在低壓區的誤差較大些。

The solubilities of uricosuric agents (probenecid and sulfinpyrazone) and the second generation sulfonylurea drug (glibenclamide) in supercritical carbon dioxide are measured with a semi-flow type equilibrium apparatus at temperatures ranging from 313.2 K to 353.2 K and pressure from 15 MPa to 31 MPa. To ensure the output stream of equilibrium cell being saturated, the minimum contact time are 1500 s , 750 s , 1000 s for probenecid, sulfinpyrazone, glibenclamide, respectively. Over the experimental conditions, the solubilities are ranging from 0.13 × 10-5 ~ 1.45 × 10-5 for probenecid, 0.29 × 10-5 ~ 2.21 × 10-5 for sulfinpyrazone, and 0.065 × 10-5 ~ 1.64 × 10-5 for glibenclamide. The solubility data are correlated with two semi-empirical density-based models, including the Chrastil model and the Mendez-Santiago-Teja model. The deviations are within the experimental uncertainty. The Peng-Robinson equation of state with two parameters van der Waals mixing rules was adopted to correlate the solubility data. In general, the correlation results are reasonably well, expect for low pressure region.

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