在本研究中，將四氧化三鐵奈米粒子與具生物相容性的光固化樹脂混合，接著使用光數位列印機(Digital Light Printing, DLP)製造用於培養成骨細胞的奈米複合材料，並測試細胞於材料生長及分化情形。
本研究中使用的是具生物相容性且末端被酯化成含有光反應性C = C可光可固化的聚丙二醇(Polypropylene Glycol, PPG)，並額外添加單體(EOEOEA)改善光反應性樹脂的流變性。
接著透過四乙氧基矽烷(Tetraethoxysilane, TEOS)改質四氧化三鐵奈米粒子表面，本實驗成功在四氧化三鐵表面形成一層約45nm的無定形二氧化矽，並且達到均勻單核包覆，有效降低奈米粒子本身因凡德瓦力的聚集，並增強四氧化三鐵奈米粒子於光固化樹脂中的分散能力。實驗結果顯示，四氧化三鐵奈米粒子在光反應性樹脂中最多穩定二十八天且最大穩定含量最高可達10wt％左右，在列印時列印濃度可達最大2wt%且未觀察到明顯的聚集及沉降現象產生。
使用光數位列印機在405nm波長下進行快速成型之後，得到由四氧化三鐵奈米粒子組成的奈米複合材料，接著將骨母細胞培養於光固化奈米磁性複合材料上。實驗結果證明，細胞活性明顯的提升，且加速細胞的提前分化。

In this research, we blended the magnetic nanoparticles with biocompatible and photo-curable resin. The magnetic nanocomposite was produced by using the digital light processing (DLP) 3D printer and then used for cell proliferation and differentiation.
The biocompatible and photo-curable oligomers in resin were composed of polypropylene glycol (PPG), while the end of these oligomers were esterified for the addition of photo-reactive C=C bonds. Besides, EOEOEA was also added to improve the rheological and mechanical properties of photo-reactive resin.
Then, we functionalized magnetic nanoparticles with Tetraethyl orthosilicate (TEOS) to prevent the aggregation. The thickness of amorphous silica layers were about 45nm and efficiently enhances the uniform dispersion of magnetic nanoparticles. The suspension of magnetic nanoparticles was stable in photo-reactive resin at least for 28 days. The highest amount of magnetic nanoparticles was 10wt% for a long-term uniform suspension. The maximum particle concentration of nanocomposite for DLP printing process was about 2wt% due to the emission of UV light.
After the rapid prototyping with DLP under the wavelength of 405 nm, uniform nanocomposites composed of UV-cured polymers and magnetic nanoparticles were obtained with designed structures. The culture of osteoblasts was carried out on the 3D magnetic scaffolds. It show that the magnetic nanoparticles promote the cell proliferation and differentiation.

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