研究生: |
譚裎諺 Cheng-Yan Tan |
---|---|
論文名稱: |
利用噴霧乾燥法合成58S生物玻璃微球及其性質鑑定之研究 Synthesis and characterization of granulated 58S bioglass microspheres using spray drying |
指導教授: |
施劭儒
Shao-Ju Shih |
口試委員: |
林穎志
Ying-Chih Lin 宋振銘 Jenn-Ming Song 周育任 Yu-Jen Chou |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 材料科學與工程系 Department of Materials Science and Engineering |
論文出版年: | 2019 |
畢業學年度: | 107 |
語文別: | 中文 |
論文頁數: | 170 |
中文關鍵詞: | 噴霧乾燥法 、生物活性玻璃 、造粒 、生物活性 、細胞毒性 |
外文關鍵詞: | Spray drying, Bioactive glass, Granulation, Bioactivity, Cytotoxicity |
相關次數: | 點閱:223 下載:0 |
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皮膚老化最常見的特徵是法令紋、魚尾紋等皺紋出現於臉上,為了減少衰老的跡象,於臉部進行注射式植入劑手術則提供了治療臉部衰老的選擇,理想的注射式填充材料應具有生物相容性、生物降解性及低風險之過敏反應,而由於生物活性玻璃 (Bioactive glass, BG) 其優異的生物活性及可降解性,已被使用於各種臨床應用,如骨替代材料、牙科填料、藥物載體和軟組織填充劑,因此BG受到極大關注具有前景之生醫材料。
本研究先以不同前驅物濃度 (0.6M、1.2M、1.8M及2.4M) 利用噴霧乾燥法製備58S BG粉體,並選用1.8M作為BG之前驅物濃度,再以噴霧乾燥法分別利用0.5、1.0、5.0和10.0wt%之聚乙烯醇縮丁醛 (Polyvinyl butyral, PVB) 、聚乙烯吡咯烷酮 (Polyvinyl pyrrolidone, PVP) 及聚乙烯醇 (Polyvinyl alcohol, PVA) 作為黏結劑製備造粒粉體,由掃描式電子顯微鏡(Scanning electron microscope, SEM)結果顯示以PVA製備之造粒顆粒具有較佳之形貌,最終以利用0.5、1.0、5.0和10.0wt% PVA製備之BG造粒粉體於800°C持溫5小時進行熱處理以形成BG微球。
利用X光繞射儀、掃描式電子顯微鏡及能量散射光譜儀分別進行粉體的晶相分析、表面形貌觀察、粒徑尺寸分佈及化學成分的分析,此外將0.5、1.0、5.0和10.0wt% PVB、PVP及PVA配置之BG漿料各別以流變儀進行黏度測試,最後將BG微球浸泡於人體模擬體液進行體外生物活性試驗及根據ISO10993-5規範進行體外細胞毒性測試。
從SEM影像中可以觀察出以5.0wt% PVA製備的BG微球具有最均一的粒徑大小。由體外生物活性測試結果得到生物活性的高低順序為0.5 > 1.0 > 5.0 > 10.0wt% PVA所製備的BG微球。此外,在體外細胞毒性測試顯示,透過5.0及10.0wt% PVA所製備BG微球的細胞存活率可以通過生物相容性的標準(70%),然而以0.5及1.0wt% PVA所製備之BG微球的細胞存活率則低於70%。
比較不同BG微球的生物活性及細胞毒性,在同時考慮此兩種性質分析顯示,由5.0wt% PVA製備的BG微球具有最佳表現。
As the skin ages, the most common features are nasolabial folds, crow’feet and rhytides on the face. In order to reduce the signs of aging, injectable facial fillers offer an option in the treatment of facial aging. The ideal injectable filler should be biocompatible, biodegradability, a low risk of allergic reaction. Bioactive glasses (BGs) have been received substantial attention in recent years due to their excellent bioactivity and degradability. Therefore, BGs have been used as a promising biomaterial for various clinical applications such as bone substitutes, dental fillers, drug carriers and soft tissue fillers. Binders are required in this study for granulate particles.
In the present study demonstrated that 58S BG powders were firstly prepared from 0.6M, 1.2M, 1.8M and 2.4M precursor solutions using spray drying method. After that, the BG powder prepared from 1.8M precursor solution as a primary powder was selected to granulate with 0.5, 1.0, 5.0 and 10.0wt% Polyvinyl butyral (PVB), Polyvinyl pyrrolidone (PVP), and Polyvinyl alcohol (PVA), respectively using spray drying method. From Scanning electron microscope (SEM) results showed granulated BG microspheres with PVA have better morphologies. Eventually, the granulated BG microspheres with 0.5, 1.0, 5.0 and 10.0wt% PVA heated at 800℃ for 5h.
Characterizations of phase composition, morphology, chemical composition, particle size and distribution for granulated microspheres were performed by X-ray diffractometer, Scanning electron microscope and Energy dispersive spectroscopy. In addition, the rheological properties of BG slurries treated with 0.5, 1.0, 5.0 and 10.0wt% PVB, PVP and PVA were measured by Modular compact rheometer, respectively. At last, in vitro bioactivity was examined by immersed in simulated body fluid. and in vitro cytotoxicity of the granulated BG microspheres were assessed by MTT assay based on ISO10993-5.
Firstly, from the SEM images of granulated BG microspheres could observe that the 5.0wt% PVA granulated BG microsphere possessed the most uniform particle size in all specimens. For in vitro bioactivity tests, the results showed an order of bioactivity is granulated 58S BG microspheres with 0.5 > 1.0 > 5.0 > 10.0wt% PVA . Furthermore, the in vitro cytotoxicity results revealed that cell viabilities of granulated BG microspheres with 5.0 and 10.0wt% PVA have passed through the standard of biocompatibility (70%). However, the cell viabilities of granulated BG microspheres with 0.5 and 1.0wt% PVA lower than 70%.
To compare the bioactivity and cytotoxicity of each specimen, indicating the 5.0wt% PVA granulated BG microsphere has optimal exhibition, which takes into account this two characterizations simultaneously.
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