人眼中的自然水晶體為透明且可讓光線自由通過的結構，然而隨著年齡增長、眼睛因外力受傷、遺傳性、眼睛病變、高度近視等因素，對水晶體的功能及構造造成不可逆的影響，進而導致水晶體混濁而最終形成白內障。白內障最常見的治療方式為進行超音波晶體乳化術，將變質的水晶體置換成人工水晶體，讓患者恢復一定的視力。本論文旨在透過設計生物相容性相符的疏水性類壓克力材料，P4H30S製成之多焦點折射/繞射型非球面人工水晶體，並依據其幾何結構繪製出相對應的模具，藉由臺大之單點鑽石切削設備來製作，其中刀具旋轉角度及刀尖半徑會成為加工路徑規劃上的一些拘束及限制，故需在加工前做好預先分析，為避免撞機發生的可能及選出最合適的刀具進行精密加工，以利取得鏡面結構。接著，將調配好的疏水性類壓克力材料灌注到模具裡，再把模具放置到烤箱對材料進行加熱固化，與此同時，建立出以真實環境為基礎的數位模型。此模型涵蓋了使用有限元素法(FEM)建立之人工水晶體與應用計算流體力學(CFD)於空氣、液體材料三種物理模型，並分析多相流在模具裡的流動影響，以不同傾斜角度灌注液體材料到模具之中，觀察氣泡產生的多寡。接續透過給定的溫度變化曲線來取得模擬人工水晶體熱固化的結果，其液體材料內部之熱傳及固化過程中所產生的翹曲變形及應力分布皆將予以重點考慮在所建立之模型。本文中針對所設計的人工水晶體進行建模與模擬，並引入真實液體材料在所開發的模具中灌注成型和熱固化的結果，進行比較和驗證。透過流體和結構分析結果顯示，該模型可反映出與真實人工水晶體製程相似的氣泡產生和變形破壞之趨勢。

The natural crystalline lens in the human eye is a transparent structure that allows light to pass through freely. However, factors such as aging, eye injuries, genetic factors, eye diseases, and high myopia can irreversibly affect the function and structure of the lens, leading to its clouding and the formation of cataracts. The most common treatment for cataracts is phacoemulsification, which is one of the cataract surgeries that supersedes the deteriorated lens with an Intraocular Lens (IOL) to restore vision.This study aims to design a hybrid refractive-diffractive IOL with a hydrophobic, biocompatible material, P4H30S. The corresponding molds are created based on the proposed geometric structure and manufactured using a Single-Point Diamond Turning (SPDT) machine. The rotational angle and nose radius of the cutting tool impose constraints and limitations on the cutting path, necessitating pre-analysis to avoid potential collisions or tool interference and choose the most appropriate tool for ultra-precision machining to achieve a nanoscale-precision structure. Next, the blended material is injected into the molds and cured by heating in an oven. Meanwhile, a numerical model based on the real environment is established.This model encompasses the IOL created using the Finite Element Method (FEM) and applies Computational Fluid Dynamics (CFD) to analyze the flow of multiphase fluids inside the molds, particularly observing the generation of air bubbles during the injection of materials at different tilt angles. The simulation results of the heat curing process of the IOLs, including internal heat transfer, resulting deformation, and stress distribution, are also investigated based on given temperature variation curves.The modeling and simulation of the IOL in this study is compared and validated by introducing liquid materials into the fabricated molds for the injection and curing processes. The fluid and structural analyses results demonstrate that the model reflects similar trends in air bubbles formation and deformation or even material failure to those observed in the actual manufacturing process of IOL.

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