牙周病與齲齒患者容易面臨齒槽骨萎縮等問題，在植牙的過程中齒槽骨之寬度與高度會影響植體的穩定度，為了填補齒槽骨的不足需要進行引導骨再生術以利於後續的植牙程序，除此之外引導骨再生術可應用於拔牙後之齒槽骨保存，能預防齒槽骨流失的情況發生。材料上選擇膠原蛋白，其具有生物相容性、可降解性與良好的凝血功能，但機械性質較差，因此添加生物活性玻璃(Bioactive glass, BG)來改善問題，透過摻雜鍶增加成骨細胞活性並促進新骨生長。
本研究以將實驗分為固含量與粒徑大小兩階段，藉此設計出符合臨床上應用於引導骨再生之牙填充材。複合支架會透過掃描式電子顯微鏡、水銀測孔儀與萬用試驗機來分析支架結構、孔隙度、孔洞大小與抗壓強度，並評估複合支架體外細胞活性、生物降解行為與膨潤度。第一階段為不同Sr-BG粉末固含量(0、10、20、30和40 wt%)之複合支架，粉末固含量會改變支架孔隙度與抗壓強度，進而影響骨頭生長和血凝塊穩定性，其中以20 wt% Sr-BG之複合支架具有最大的抗壓強度與高孔隙度為最佳固含量。第二階段為不同粒徑大小(1、7、11和42 µm) Sr-BG粉末之複合支架，粉末粒徑會影響生物活性、體外細胞活性與降解行為，根據實驗結果以11 µm Sr-BG粉末的生物活性最好，且複合支架體外細胞活性高於100%代表具有生物相容性，而支架降解行為隨著粒徑越大其降解速度越慢。

Patients with periodontal disease and tooth decay are prone to symptoms of alveolar bone atrophy. The width and height of the alveolar bone will affect the stability of the denture implants. About this problem, guided bone regeneration can improve. In addition, it also uses for the preservation of alveolar bone after tooth extraction, which can avoid the problem of alveolar bone loss. Collagen has good biocompatibility, biodegradation, and blood coagulation function. Bioactive glass can improve the mechanical properties of the scaffold and enhance the bone growth ability through strontium.
In this study, The experiment divides into two parts of solid contents and particle sizes for design the scaffold to meet the clinical application of dental filling materials for guided bone regeneration. We analyze the scaffold's structure, porosity, pore size, and compressive strength through the scanning electron microscope, mercury porosimeter, and universal testing machine. Also, evaluate scaffold in vitro cell viability and biodegradation. The first part analyzed composite scaffolds with different Sr-BG powder solid content (0, 10, 20, 30, and 40 wt%). The solid content affects the porosity and compressive strength of the scaffold, therefore affecting bone growth and blood clot stability. According to the compressive strength and high porosity, obtained 20 wt% Sr-BG as the best solid content of the scaffold. The second part analyzed composite scaffolds with different particle sizes (1, 7, 11, and 42 µm). According to the experimental results, the best bioactivity of particle size is 11 µm Sr-BG. Also, the in vitro cell viability of the 11 µm composite scaffold is higher than 100%, which means that it has biocompatibility, and the degradation behavior of the scaffold is slower with the larger particle size.

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