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研究生: 劉憓陵
Huey-ling Liu
論文名稱: PGA/PVA混摻薄膜接枝左旋維他命C探討
Investigation of PGA/PVA blend membrane grafted with L-vitamin C
指導教授: 楊銘乾
Ming-Chien Yang
口試委員: 蘇清淵
Ching-Iuan Su
于大光
none
學位類別: 碩士
Master
系所名稱: 工程學院 - 材料科學與工程系
Department of Materials Science and Engineering
論文出版年: 2006
畢業學年度: 94
語文別: 中文
論文頁數: 46
中文關鍵詞: 聚麩胺酸聚胜肽聚乙烯醇戊二醛左旋維他命C
外文關鍵詞: PGA, polypeptides, PVA, glutaraldehyde, Ascorbic
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  • Na+-γ-poly(glutamic acid) (PGA)為一具有奇佳的高吸水性、生物可分解性、保濕性、無毒性等優良特性之高分子聚合物,因此用來與聚乙烯醇
    (PVA)混摻製成薄膜。兩種高分子在室溫下且不需任何化學藥劑的條件下,PGA和PVA即可混合形成水膠。依不同比例之PGA/PVA (0%、10%、11.1%、12.5%、20%、27.3%、30%、40%、50%) 混摻薄膜測試在生理食鹽水中之膨潤度,證實其具有高吸濕性,之後以戊二醛與左旋維他命C共價結合,運用左旋維他命C之抗氧化能力,期能增加PGA/PVA混摻薄膜在生醫材料及化妝保養品產業上的應用。


    Na+-γ-poly(glutamic acid) (PGA), a highly water-soluble, biodegradable, hygroscopic and non-cytotoxic polypeptides, was
    chosen to fabricate the PGA/polyvinyl alcohol (PVA) blending membranes. By mixing PGA and PVA together, a hydrogel would
    be formed at room temperature without any chemical treatment.It was proven to be a highly hygroscopic by mixing at different ratio
    of PGA/PVA (0~50%) blending membranes for testing its swelling
    ratio in normal saline. By glutaraldehyde to covalently bond L(+)-Ascorbic acid with PGA/PVA, the application of PGA/PVA
    blending membranes can be broadened in medical devices and
    cosmetic industries.

    摘要 Abstract 目錄 圖目錄 表目錄 第一章緒論 1.1 前言 1.2 研究目的 第二章文獻回顧 2-1醫療保健材料發展之趨勢及應用 2-2美白機制之概述 2-3聚麩胺酸介紹 第三章實驗方法 3-1藥品與材料 3-2 實驗儀器 3-3實驗步驟 3-3-1 實驗流程 3-3-2 PGA-PVA水膠膜製作 3-4膨潤度試驗 3-5左旋C接枝率試驗 3-6電子掃描顯微鏡(SEM) 3-7蛋白質吸附試驗-HSA的吸附試驗 3-8血小板吸附試驗 3-9 化學發光分析試驗(抗氧化能力分析) 3-10 細胞毒性 MTT色度分析法 第四章 結果與討論 4-1膨潤度試驗 4-2.左旋C接枝率試驗 4-3 電子顯微鏡 4-4蛋白質吸附 4-5血小板吸附 4-6化學發光分析試驗(抗氧化能力分析) 4-7 細胞毒性 第五章 結論 未來展望 參考文獻

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