本研究使用再循環裝置量測六組三成分系統在一大氣壓下1,4-dioxane (1) + water (2) + TRIS (3)，1,4-dioxane (1) + water (2) + EPPS (3)，1,3-dioxolane (1) + water (2) + TRIS (3)，1,3-dioxolane (1) + water (2) + EPPS (3)，THF (1) + water (2) + TRIS (3)和THF (1) + water (2) + EPPS (3)之恆壓汽液平衡數據。所添加生物緩衝液的濃度範圍是從質量分率0.05至0.15。加入生物緩衝劑TRIS後，在1,4-dioxane水溶液、1,3-dioxolane水溶液以及tetrahydrofuran水溶液中，環醚類之汽相組成及水溶液共沸點組成皆明顯往有機成分增高的方向移動，且移動的效果依TRIS濃度增加而更明顯。加入生物緩衝劑EPPS後，1,4-dioxane水溶液以及tetrahydrofuran水溶液之汽相組成往有機成分端移動，且移動的效果依EPPS濃度增加而更明顯。加入生物緩衝劑EPPS於1,3-dioxolane水溶液時，1,3-dioxolane之液相組成、汽相組成及平衡溫度只有輕微改變。實驗所得之相平衡數據以NRTL模型來關聯以求取雙成分交互作用參數最適值。針對本研究的系統，NRTL模型關聯之結果與汽液相平衡實驗數據相符合。然而，使用NRTL模式關聯三成分系統液液相平衡之交互作用參數無法和汽液相平衡數據相符，如要準確計算汽液相平衡性質，必須使用由汽液相平衡數據所訂定的交互參數值，將這些NRTL模式之參數值應用於製程模擬，方能可靠評估由蒸餾塔回收生物緩衝劑的操作效能。

Isobaric vapor-liquid equilibrium (VLE) data were measured for six ternary systems of 1,4-dioxane (1) + water (2) + TRIS (3), 1,4-dioxane (1) + water (2) + EPPS (3), 1,3-dioxolane (1) + water (2) + TRIS (3), 1,3-dioxolane (1) + water (2) + EPPS (3), THF (1) + water (2) + TRIS (3) and THF (1) + water (2) + EPPS (3) at 101.32 kPa by using a modified recirculating type of Othmer equilibrium still. The concentration range of the added biological buffer is from 0.05 to 0.15 in mass fraction. The presence of TRIS induces significantly azetropic composition shifting for the aqueous 1,4-dioxane, 1,3-dioxolane and tetrahydrofuran systems. In the presence of EPPS in aqueous 1,4-dioxane and tetrahydrofuran systems, the azeotropic composition shifting effect was also found substantially, while only minor effect on the VLE behavior was found from the aqueous 1,3-dioxolane system. The experimental VLE data were correlated with the NRTL model to determine the binary interaction parameters. Generally, the NRTL model correlate reasonably well for the systems investigated in this study. These new VLE ternary data of EPPS-containing systems were also taken as a basis for evaluating the applicability of the binary parameters determined from the liquid-liquid equilibrium (LLE) data for predicting the VLE properties. Large discrepancy was found from this evaluation, and indicating that the simulation of buffer-recovery distillation column should use the parameters determined from the VLE data.

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