自1971年起，由於生物活性玻璃(Bioactive glass, BG)的生物活性與其廣泛的潛在應用，例如骨值體、牙齒填充物、藥物載體，因而吸引了廣大的注目。BG會在其表面形成氫氧基磷灰石(Hydroxy apatite, HA)層，當被植入人體時，將與組織產生強力的化學鍵結。為了增加HA的形成，合成介孔生物活性玻璃(Mesoporous bioactive glass, MBG )以增加表面積為最常使用的方法之一。在骨值體內生長的細菌可能導致感染，但可藉由添加抗菌劑來克服，例如銀(Silver, Ag)。合成銀摻雜的MBG之製程中，溶膠凝膠法為最受歡迎的製程，然而此製程有不連續、時間過長、不適合大量生產的缺點。為了克服這些缺點，選擇使用噴霧熱裂解(Spray pyrolysis, SP)作為合成銀摻雜的MBG之替代製程。本研究成功利用SP與前驅物矽酸乙酯(Tetraethyl orthosilicate, TEOS)、四水硝酸鈣(Calcium nitrate tetrahydrate)、磷酸三乙酯(triethyl phosphate, TEP)、醋酸銀(silver acetate, AgA)、醋酸銀(silver nitrate, AgN)成功合成銀摻雜的MBG。利用XRD、SEM、TEM、氮氣吸脫附法(BET)分析粒子特性，並藉由冷凍切片分析粒子剖面的元素分布，使用ICP分析銀摻雜的MBG之溶解散佈剖面圖。藉由將粒子浸泡在人體模擬體液中幾小時以分析試管中的生物活性，再以XRD分析其特性。使用抗菌圈進行抗菌測試。銀摻雜的MBG有良好的生物活性且達成抗菌效果，也得到銀的分布與粒子的形成機制。

Bioactive glass (BG) has attracted the attention of researchers for the last 50 years since it firstly reported at 1971 because of the bioactivity properties, and wide potential applications such as bone implants, tooth filling materials, and drug carriers. Bioactive glass forms hydroxyapatite (HA) layers on the surface of the BG that will generate strong chemical bond with tissue when it is implanted in a human body. To increase the HA formation, one of the popular approaches is to increase the surface area of BG by synthesize mesoporous bioactive glass (MBG). One of the applications of Mesoporous bioactive glasses are as bone implants that face a major problem with bacterial infections. The growth of bacteria in the bone implant that could lead to infection could be overcome by doped MBG by antibacterial agent such as silver (Ag). Sol-gel method is the most popular procedure to synthesize Ag-doped MBG; however, this method has some drawbacks of discontinuous processing, long processing time and unsuitable for mass production. To overcome these drawbacks, spray pyrolysis (SP) is an alternative procedure to synthesize Ag-doped MBG. In this study, Ag-doped MBG was successfully synthesized by using SP with tetraethyl orthosilicate, calcium nitrate tetrahydrate, triethyl phosphate, silver acetate and silver nitrate as the Ag-doped MBG precursors. The MBG particles will be characterized by using X-ray diffraction, scanning electron microscopy, transmission electron microscopy and nitrogen adsorption/desorption isotherm for their crystallography structures, surface morphologies, and specific surface areas. Particles chemical element distributions were analyzed by using X-ray energy dispersive analysis and the dissolution profile of Ag-doped MBG is characterized using inductive coupled plasma for chemical analysis. The invitro bioactivity properties was analyzed by immersing the particles into simulated body fluid for certain hours and characterized by X-ray diffraction. Antibacterial property tests were conducted by using zone of inhibition method. Ag-doped MBG that with superior bioactivity and antibacterial properties were achieved by using the SP process, and silver distributions and particle formation mechanisms were also discussed.

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