球形 β三鈣磷酸鹽顆粒可提高對於3D列印骨移植支架的品質。為了達到大量生產、球形形態和高產率的β-三鈣磷酸鹽，本研究選擇以噴霧乾燥技術來製備 β-三鈣磷酸鹽顆粒。
在本研究以兩種不同的方式製備β-三鈣磷酸鹽顆粒，分別為未處理以及經過甲酸處理的前驅液，噴霧乾燥法成功合成未處理和甲酸處理的β-三鈣磷酸鹽顆粒，將合成的顆粒以不同溫度(800、900、1000和1100 ℃)進行煅燒，並分析其相組成、粉體形貌、化學組成以及比表面積。此外，以體外細胞毒性 (MTT) 和體外生物降解試驗用於評估作為骨移植應用的性能。實驗結果顯示，未處理的β-三鈣磷酸鹽 顆粒有較低純度相組成、片狀顆粒形貌且含有毒性。而經過甲酸處理的 β-三鈣磷酸鹽 顆粒具有高純度相組成、實心且光滑的球形顆粒、良好的生物降解性且無毒性。此外，經過甲酸處理的β-TCP顆粒在800 oC 煅燒後具更高的比表面積、高孔隙率、無毒性且較低的煅燒溫度為最本研究最佳的實驗條件。

Spherical β-TCP particles can help improve the quality of 3D printed bone graft scaffolds. In order to produce β-TCP for mass production, spherical morphology and high yield product, spray drying was chosen as a technique to prepare β-TCP particles.
β-TCP particles were prepared in two distinct ways, namely un-treated and formic acid-treated β-TCP particles. The spray drying method was successfully used to fabricate both untreated and formic acid-treated β-TCP particles. The synthesized particles were calcined at various temperatures (800, 900, 1000, and 1100 ℃). Characterizations of phase composition, morphology, chemical composition, and specific surface area were carried out. In addition, in vitro cytotoxicity (MTT) and biodegradability tests were used to evaluate performance as bone graft applications. The results showed that un-treated β-TCP have a low purity phase, flake-like morphology, and non-toxicity. However, formic acid-treated β-TCP has a high purity phase, solid spherical morphology, good biodegradability, and non-toxicity. Moreover, 800 oC calcined of formic acid-treated β-TCP particles were chosen as the most suitable candidate because it has a higher surface area, high porosity, non-toxicity, and lower calcination temperature.

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