目前罹患糖尿病人口日趨增加，傷口感染所需之醫療需求提高，能防止傷口感染並促進傷口癒合之敷料能改善以上問題。在傷口敷料中生醫玻璃作為可吸收性生醫陶瓷，其中磷基生醫玻璃具有良好降解速率，經由離子釋放加速傷口復原，在製作傷口敷料應用上具有潛力。製程方面中噴霧熱裂解法具有控制產物比例、顆粒及形貌的優勢，本次研究利用此法製備矽基與磷基生醫玻璃粉末。
本研究內容分為三個部分，第一部分由不同前驅液濃度製備出76S 矽基生醫玻璃粉末，第二部分由不同成分與鍛燒溫度製備出14P、24P和34P磷基生醫玻璃粉末，再分別對晶體結構、顆粒大小與形貌、比表面積和降解性質進行分析與探討。第三部分則是建構出76S、14P、24P和34P模型，探討不同成分比例之結構與性質差異。在第一部分的分析中，平均粒徑隨著前驅液濃度提高而上升，同時比表面積下降，降解速率減緩。第二部分，結晶溫度隨著磷含量增加而降低，磷含量成分增加使得磷基生醫玻璃的降解速率提升。第三部分，模擬結構中觀察到增加磷的比例使非架橋氧的比例增加，更能限制結構間的交聯，增加生物降解性的能力。因此未來將根據患部的需求來調控生醫玻璃的性質，若需要為具有高穩定性的生醫玻璃選擇前驅液為0.3或0.5 M的76S BG，若尋求具有快速降解性質的生醫玻璃則選擇24P或34P的磷基生醫玻璃。

The number of people with diabetes is increasing, leading to a higher demand for medical care for wound infections. Dressings that can prevent wound infections and promote healing can effectively address these issues. Among various wound dressings, bioactive glass, as an absorbable bioceramic, shows significant potential. In particular, phosphate-based bioactive glass, with its excellent degradation rate, can accelerate wound healing through ion release, making it highly promising for wound dressing applications. Spray pyrolysis offers advantages in controlling product composition, particle size and morphology. This study uses this method to prepare silica-based and phosphate-based bioactive glass powders.
The study is divided into three parts: the first part involves preparing 76S silica-based bioactive glass powders with various precursor concentrations; the second part involves preparing 14P, 24P, and 34P phosphate-based bioactive glass powders with various compositions and calcination temperatures, followed by analysis of their crystal structure, particle size and morphology, specific surface area and degradation properties. The third part constructs models of 76S, 14P, 24P, and 34P to explore the structural and properties based on various compositions. In the first part, the analysis shows that the average particle size increases with the precursor concentration, while the specific surface area decreases, and the degradation rate slows down. The second part reveals that with increased phosphorus content, the crystallization temperature decreases, enhancing the degradation rate of the phosphate-based bioactive glass. The third part's simulated structures indicate that increasing the phosphorus ratio increases the proportion of non-bridging oxygen, limiting cross-linking between structures and enhancing biodegradability. Therefore, in the future, the properties of bioactive glass will be controlled according to the needs of the affected area. If needs high stability bioactive glass, select 76S BG with a precursor solution of 0.3M or 0.5M. If needs high degradation rate, select 24P or 34P phosphate-based bioactive glasses.

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