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研究生: 焦良偉
Liang-wei Chiao
論文名稱: 以信號處理技術偵測血液透析患者廔管通路狹窄之研究
A Study of Detecting The Arteriovenous Graft Stenosis for Hemodialysis Based on Signal Processing Technique
指導教授: 陳志明
Chih-Ming Chen
王延年
Yen-nien Wang
口試委員: 陳建中
Jiann-Jone Chen
學位類別: 碩士
Master
系所名稱: 電資學院 - 電機工程系
Department of Electrical Engineering
論文出版年: 2009
畢業學年度: 97
語文別: 中文
論文頁數: 81
中文關鍵詞: 血液透析動靜脈廔管短時傅立葉轉換定位平均濾波器
外文關鍵詞: hemodialysis, arteriovenous graft, short-time Fourier transform, align and average filter
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  • 在本論文中,利用信號處理技術分析血液透析病患動靜脈廔管的血流聲信號,並且提供一個偵測廔管狹窄與否的演算法,統計分析病患得到一結論。血流信號的組成包括了一個1~1.67Hz之間的基頻信號,以及一個頻寬隨血管的阻塞程度而定的載波,因此利用基頻資訊,在觀察其中載波的成分,可以得知血管狹窄的程度。而本演算法困難點在於信號與脈動有關的低頻成份(1~1.67Hz)以及與代表血流聲的高頻成份(300Hz以上),其能量大小相差約100dB,高頻是判斷的依據,但其能量相對太小造成的正確判讀的困難性。在一開始,我們先以短時傅立葉轉換對信號進行分析,藉由觀察信號時頻域的能量分佈,探討廔管狹窄對血流聲音信號的影響。接著以設計的定位平均濾波器處理信號中的雜訊問題,再用數位濾波器來選取待測信號的特定頻寬成份。
    我們的演算法判斷結果中,Miss Fire的機率在5 %以內,但是False Alarm的機率大約23%是需要以後再改進的部份。


    In this thesis, we analyzed the acoustic signal from the hemodialysis patient’s arteriovenous graft, and developed an algorithm for stenosis detection. Based on our analysis, we found that their blood flow generates a baseband signal which is between 1 to 1.67Hz over a carrier whose frequency range is highly correlated to the stenosis level in the arteriovenous graft. The carrier signal is much weaker(less than -100dB) than the baseband signal, as a result it is very difficult to observe the carrier directly and come up with a reliable detection result. By analyzing the signal in the time-frequency domain, we design an align-and-average scheme to suppress possible noises, and based on our analysis and observation, an array of cascaded bandpass filters are applied for detection purpose.
    Using our new technique, the results have been proved to within 5% of miss fire rate. The false alarm rate is about 23%, unfortunately. This leaves room for future improvement, however.

    目錄 第一章 緒論 1 1.1 簡介 1 1.2 研究動機與目的 2 1.3 論文大綱 3 第二章 相關背景 5 2.1 簡介 5 2.2尿毒症 5 2.3血液透析 7 2.3.1血液透析簡介 7 2.3.2 動靜脈廔管 8 2.4血液 11 2.4.1血液動力學 11 2.4.2血液流動模型 14 2.5文獻探討 17 第三章 動靜脈廔管信號分析 19 3.1 簡介 19 3.2 時頻分析 21 3.2.1短時傅立葉理論 21 3.2.2短時傅立葉分析 23 3.3 Align & Average 濾波器 29 3.3.1 Align & Average介紹 29 3.3.2定位方法 34 3.2.3峰值追蹤法 45 3.4狹窄判別演算法 51 3.4.1數位濾波器 51 3.4.2頻帶切割 53 第四章 實驗過程與結果 58 4.1 簡介 58 4.2資料擷取 58 4.2.1 軟硬體介紹 58 4.2.2 資料選擇 61 4.2.2.1 超音波量測 62 4.2.2.2 聽診器量測 64 4.2.2.3 血管攝影照片 66 4.3 實驗結果 67 第五章 結論與未來研究方向 74 5.1 結論 74 5.2 未來研究方向 75 參考文獻 79

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