隨著科技及醫療的發展，使得世界人口平均壽命延長，人口老化所面臨的問題逐漸浮現。隨著年齡增長，正常的老化過程會導致各種生理功能退化，據統計，老年人跌倒是事故傷害的第二大原因，跌倒造成的骨折或是頭部外傷將增加感染及罹患病症的機率。根據報導，台灣罹患糖尿病症的患者中，老年人佔據超過四成比例，且糖尿病患者的傷口癒合能力低，此時若老人跌倒骨折受傷產生傷口，同時又患有糖尿病，將容易於手術期間感染，輕則發炎反應，重則危及生命。
老年人的復原能力較差，而介孔生物活性玻璃(Mesoporous Bioactive glass, MBG)具有生物活性且可負載藥物於其孔洞中，將負載藥物的MBG放入人體中時，會在材料表面生成氫氧基磷灰石(Hydroxyapatite, HA)，可以有效幫助骨骼修復，且負載的藥物可降低細菌感染的機率，是一種良好的生醫及藥物載體材料，本研究利用噴霧熱解法(Spray pyrolysis, SP)並添加不同濃度的甲酸、醋酸及乳酸作為造孔劑製備高比表面積介孔生物活性玻璃，提升比表面積不但可以提升生物活性，更能增加藥物負載量。本研究結果顯示，高比表面積的MBG同時具有高生物活性及高藥物釋放量等特性。

With the development of science and technology and medical care, the average life expectancy of the world's population has prolonged, the problems faced by the aging population have gradually emerged. With age, the normal aging process will lead to the degradation of various physiological functions. According to statistics, the fall of the elderly is the second leading cause of accidental injuries. Fractures caused by falls or head trauma will increase the risk of infection and illness. According to reports, among the patients with diabetes in Taiwan, the elderly account for more than 40%, and the wound healing ability of diabetic patients is low. At this time, if the old man falls and fractures and wounds, and he has diabetes, it will be easy to be infected during surgery. It is an inflammatory reaction, but it is life-threatening. The resilience of the elderly is poor, and Mesoporous Bioactive glass (MBG) is biologically active and can carry drugs in its pores. When the drug-loaded MBG is placed in the human body, it will produce hydrogen and oxygen on the surface of the material. Hydroxyapatite (HA) can effectively help bone repair, and the loaded drug can reduce the chance of bacterial infection. It is a good biomedical and drug carrier material.
In this study, spray pyrolysis (SP) and different concentrations of formic acid, acetic acid and lactic acid were added as pore-forming agents to prepare high specific surface area mesoporous bioactive glass. Increasing the specific surface area not only improved biological activity, but also increased drug load. the amount. The results of this study show that MBG with high specific surface area has high bioactivity and high drug release.

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