頸背部及肩頸部酸痛、上肢有麻木感或感覺異常，是現代人常見的問題。此情形若是發生在老年人身上，多半為頸椎椎間盤產生退化，嚴重的頸椎椎間盤退化會導致頸背疼痛或神經病變等症狀。頸椎人工椎間盤置換手術可以解除脊椎疼痛並能保留頸椎活動範圍，近幾年來在歐、美各國及日、韓等國都積極的發展這種頸椎人工椎間盤置入物的技術。
頸椎人工椎間盤置換手術，是將人工椎間盤直接嵌入上下兩頸椎椎體以達到穩固，在臨床上發現人工椎間盤在植入後會有滑脫現象產生，因此人工椎間盤與頸椎接觸介面之設計是重要的，然而關於介面參數化分析的研究是很少見。本研究目的主要為使用有限元素法模擬頸椎人工椎間盤在椎體間滑脫的狀態，探討改變人工椎間盤之板型、齒型、孔數、齒距、齒高、齒寬對於拉出強度之影響，並以田口方法得到頸椎人工椎間盤之最佳化設計，另與市售產品作拉出強度之比較。
本研究所得到之結論為在小面積的接觸介面上，有設定磨擦係數與未設定磨擦係數，其分析結果趨勢具有一致性，因此有無設定磨擦係數對於分析結果影響並不大。在田口參數化分析所得的最佳化設計，顯示齒型截面積越大其拉出強度也隨之增加。最佳化設計的拉出強度也比三款市售人工椎間盤高出許多。

Nape ache, shoulder ache, and upper limbs with anaesthesia are commonly problems for people. If those problems occurred to old people, they might lead to the degradation of the intervertebral disc in cervical vertebra, the nape paining, and the symptom of the neuropathy. The total disc replacement (TDR) of cervical vertebra can be used to treat the vertebra pain and keep its range of motion (ROM). The artificial disc for cervical vertebra has been developed by Europe, U.S.A., Japan, Korea and etc. in recent years.
The rationale of the cervical TDR is that the artificial disc is implanted into the area between two cervical vertebral bodies to maintain the stabilization. In clinical point of view, the artificial disc loosening was found after a short period of the orthopaedic surgery. Therefore, it is necessary to improve the interface strength between the artificial disc and the cervical vertebrae. However, the biomechanical study on the interface strength of the cervical artificial disc is rare. The purposes of this study of this study were to investigate the interface strength of the cervical artificial disc by using the finite element (FEM) and to find the effects of each design variable of the artificial disc (the plate type, shape of spike, holes, spike distance, spike height, and spike wide) by using Taguchi method. In addition, the optimum design obtained in this study would compare with the commercial designs.
In conclusion, the finite element models with or without a friction coefficient showed an identical result in the small contact area. Therefore, the effect of the friction condition is quite low. The parametric study revealed that increasing the spike area would increase the pullout strength of the artificial disc. The pullout strength of the optimum design was higher than that of three kinds of the commercial designs.

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