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研究生: 陳柏均
Po-Chun Chen
論文名稱: 使用普魯士藍作為辨識元件以EGFET量測法即時檢測鈉與鉀離子濃度
Real-time determination of sodium and potassium concentration by using Prussian blue modified extended gate field effect transistor.
指導教授: 黃崧任
Song-Jeng Huang
口試委員: 林景崎
Jing-Chie Lin
張復瑜
None
熊樂昌
Lo-Chung Hsiung
學位類別: 碩士
Master
系所名稱: 工程學院 - 機械工程系
Department of Mechanical Engineering
論文出版年: 2016
畢業學年度: 104
語文別: 中文
論文頁數: 93
中文關鍵詞: 普魯士藍延伸閘極式電晶體鉀離子量測鈉離子量測電沉積薄膜
外文關鍵詞: Prussian blue, Extended gate field effect transistor, Potassium concentration detection, Sodium concentration detection, Electrodeposition membrane
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  • 隨著現代人的飲食習慣以及生活品質的改善,逐漸出現一些常見的病症,更甚者有可能會對人生命造成很大的疑慮,腎衰竭也是其中之一,現行腎衰竭患者嚴重者需固定進行洗腎以維持基本生命需要,但有效控制血鉀離子就可以更有效的控制洗腎次數,可有效降低醫療支出,並使病患能花費更少時間金錢在這部份的開銷;普魯士藍 (Prussian blue) 是一種特殊的化學組成物,具有針對於一價離子的良好吸引力,本實驗以電沉積法在電極上修飾一層普魯士藍薄膜,在給予特殊啟動電壓,便可以使其抓取一價離子的能力大幅提升,故可以將其應用為特殊辨識元件,如此製作出來的電極就可以使用在FET上,在鈉鉀離子被抓取後,造成表面電荷的改變,來使得FET輸出的電流產生變化,以此反推得溶液中離子濃度,在完成驗證後,接著量測不同濃度的氯化鉀 (KCl) 及氯化鈉 (NaCl) 並建立資料庫,以及濃度曲線。


    With the improvement of life quality in modern society, it comes with some common diseases. Kidney failure is one of the risky diseases. Nowadays, kidney failure patients need to take a regular dialysis treatment in order to extend their lives. However, through controlling the times of dialysis treatment by the potassium concentration in blood can reduce medical expenses effectively, by which patients could save both money and time, which is more efficient.
    Prussian blue is a special chemical composition; it has good affinity for mono-ion. In this research, we use electrical deposition method to coat Prussian blue membrane on the surface of electrode. When we input specific starting voltage to the membrane, its ability to capture mono-ion increase notably. That’s the reason we apply this unique characteristic in this research. In our system, Prussian blue is the recognition element. The electrode with Prussian blue membrane can use in the field effect transistor system. After potassium and sodium ion been captured, it caused the surface charge change. Currents between source and drain will change as well. By calculating the changes of current, ion concentration in solution can be found. Finally, both potassium and sodium concertation’s database and the concentration dependent curve of the research were built up.

    摘要 I Abstract II 目錄 III 第一章 緒論 1 1.1 前言 1 1.2 研究動機與目的 2 1.3 文獻回顧 4 1.3.1 普魯士藍用於電化學量測 4 1.3.2 鈉鉀離子量測 6 1.4 文獻整理心得 10 第二章 感測器相關性質 11 2.1 生物感測器的種類 11 2.1.1 機械能量測裝置 11 2.1.2 光學式量測裝置 13 2.1.3 電化學量測裝置 14 2.2 金氧半導體場效應電晶體 (MOSFET) 的種類 17 2.2.1 N型金氧半導體 (NMOS) 18 2.2.2 P型金氧半導體 (PMOS) 19 2.2.3 互補式金氧半導體 (CMOS) 20 2.2.4 離子選擇性電晶體 (ISFET) 20 2.2.5 延伸閘極式半導體 (EGFET) 21 2.3 普魯士藍電化學特性 23 2.4 系統整合 24 2.4.1 電路系統設計 24 2.4.2 資料庫建立 25 第三章實驗方法與步驟 26 3.1 實驗方法 26 3.2 實驗流程圖 28 3.3 實驗材料 29 3.4 實驗設備 30 3.4.1 CHi電化學分析儀 30 3.4.2 電源量測單元 (Source Meter) 31 3.4.3 加熱攪拌器 32 3.4.4 FE-SEM 33 3.5 普魯士藍鍍液製備步驟 34 3.6 標準液製備步驟 35 3.7 延伸電極製作 37 3.8 量測電路配置 38 3.9 量測實驗標準流程 39 第四章結果與討論 40 4.1 電沉積參數 40 4.2 微觀組織 45 4.3 電性量測 56 4.3.1 感測面積量測 56 4.3.2 EGFET 電流量測 64 4.3.3 資料庫建立 71 第五章 結論 75 參考文獻 77

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