β-三鈣磷酸鹽 (β-tricalcium phosphate, β-TCP)是一個具有良好的化學穩定性、無毒性、高生物相容性及骨傳導性的生物材料，在骨科及牙科手術中常做為骨組織替代品使用。然而β-TCP 本身並不具抗菌及抗癌的性質。為了改善上述性質，本研究將開發以噴霧熱裂解法製備之摻雜雙金屬離子 (銀/鋅、銀/銅、銀/鐵) 的β-TCP粉體。
本研究將使用X光繞射儀 (X-ray diffraction, XRD) 及 Rietveld 精算法分析 β-TCP 晶體結構中離子的置換情形；以掃描式電子顯微鏡 (Scanning electron microscopy, SEM) 及能量色散X射線譜 (X-ray energy dispersive spectroscopy, XEDS) 進行材料形貌觀測及成分組成鑑定；以高解析穿透式電子顯微鏡 (High resolution transmission electron microscopy, HRTEM) 進行材料奈米結構之鑑定；以X射線光電子能譜儀 (X-ray photoelectron spectroscopy, XPS) 進行離子種類之鑑定。在體外實驗部分，本研究將以大腸桿菌 (Escherichia coli) 進行抗菌實驗，並進行菌落計數法分析材料之抗菌能力；而於細胞實驗上，本研究將以MTT assay對正常組之MC3T3-E1細胞及癌細胞組之MG-63細胞進行相關生物學分析。
根據晶體學之研究結果，本研究藉由波峰位置改變、晶體結構尺寸、晶格參數等數據證實摻雜之金屬離子確實置換於β-TCP的晶體結構中。此外、本研究亦顯示不同濃度及種類的金屬離子摻雜使β-TCP在大腸桿菌之實驗中具有不同抗菌強度。最後，雙離子置換之β-TCP對MC3T3-E1及MG-63細胞存活實驗的影響也將被探討。

β-tricalcium phosphate (β-TCP) is a synthetic biomaterial that present as an ideal bone tissue substitutes in orthopedic and dental surgery from the standpoints of chemically stability, non-toxicity, high biocompatibility and osteoconductivity. However, β-TCP suffer from lacks of intrinsic antibacterial and anticancer properties. Therefore, to improve the above deficiencies, the incorporation of co-ionic (silver-zinc, silver-copper, and silver-iron) in β-TCP system using a spray pyrolysis method have been proposed in this thesis.
X-ray diffraction (XRD) and Rietveld refinement were performed to explain the effect of ions substitution on the β-TCP lattice structure. The morphologies and chemical compositions were characterized using scanning electron microscopy (SEM) and X-ray energy dispersive spectroscopy (XEDS), respectively, whereas the high-resolution transmission electron microscopy (HRTEM) was employed to characterize the nanostructure. Moreover, the detail vision of ionic species was measured by X-ray photoelectron spectroscopy (XPS). On the other hand, the in-vitro antibacterial test was performed against Escherichia coli (E. coli) bacteria using colony count method. In addition, the in-vitro biological studies of substituted β-TCP were evaluated using MTT assay with MC3T3-E1 as normal cell and MG-63 as the cancer cell.
The crystallographic studies were confirmed that metal ions were substituted within the crystal structure of β-TCP, as evidenced by the change in peak position, crystallite size, and lattice parameter. Furthermore, metal ions substituted β-TCP showed varying strengths of antibacterial properties against E.coli bacteria, which was ascribed to different type and substitution concentrations of metal ions. Finally, the effect of co-ionic substitution in β-TCP on the MC3T3-E1 and MG-63 cell survival were discussed.

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