本研究利用常壓電漿製備兩性共聚物，並將製備之共聚物修飾於材料表面，目標為降低生物分子在材料上的沾粘。共聚物合成所使用之單體為丙烯醯胺 (acrylic amide, AAm)、丙烯酸 (acrylic acid, AAc) 以及硫代甜菜鹼 (sulfobetaine methacrylate, SBMA)，利用常壓電漿分別製備含醯胺基之 p(S-co-AAm) 及含羧基之 p(S-co-AAc) 兩種共聚物，探討電漿參數與製備方法對共聚高分子物化性質的影響。首先以 ATR-FTIR、1H-NMR、GPC等儀器分析共聚物之結構，接著分析經共聚物修飾樣本之表面親疏水性、表面界達電位、表面元素組成、抗蛋白質沾黏效果及生物相容性。
本研究第一部分，利用常壓電漿 (atmospheric pressure plasma jet, APPJ) 產生之自由基作為起始劑，於單體溶液內進行共聚反應。由 ATR-FTIR 分析樣本之化學官能基，並比較APPJ 聚合與傳統熱聚合所製備之共聚高分子顯示，APPJ聚合保有與熱聚合相同之化學官能基，故以APPJ製備之共聚物不會因電漿掃描而造成化學官能基的變異。以 GPC 進行分子量分析，由APPJ操作功率70 W，掃描次數10、15與20次製備p(S-co-AAm)，獲得共聚物分子量為 140 kDa、147 kDa 與 153 kDa，分散性指數為3.11、2.55 與 2.04。另一方面，當固定APPJ操作功率為 70 W，掃描次數10次，單體直接混合並以 APPJ 輔助聚合，共聚物分子量為 120 kDa，分散性指數為 4.52。若使單體經 APPJ 預聚後混合，再以APPJ掃描進行共聚，共聚物分子量為 150 kDa，分散性指數為 2.53，顯示當預聚物混合再以APPJ掃描，能有效增加小分子產物再聚合的可能。
本研究第二部分，利用共聚高分子修飾於材料表面，目標為減少材料之沾黏現象。以 APPJ 製備之 p(S-co-AAm) 修飾於基材表面顯示，TCPS表面水接觸角由 88˚ 減少至低於 10˚ 之超親水性。由蛋白質貼附結果顯示，與未經修飾之基材相比，於溶菌酶以及牛血清蛋白之貼附量分別減少 51 % ~ 60 % 以及52 % ~ 62 %。由L929細胞進行LDH assay測試結果顯示，經表面修飾後樣本仍具生物相容性。另一方面，以APPJ製備之 p(S-co-AAc) 修飾於基材，玻璃表面水接觸角由 33˚ 減少至 4˚ ~ 16˚，並由蛋白質貼附實驗顯示，溶菌酶與牛血清蛋白貼附量與空白基材相比減少了 52 % ~ 66 % 及 40 % ~ 56 %。綜合上述結果，利用 APPJ 可成功製備兩性共聚高分子，並透過 APPJ 參數的調整可進行分子量大小的調控。在材料表面應用上，能有效增加基材之表面親水性與非特異性抗沾黏的效果，故 APPJ-p(S-co-AAm) 及 APPJ-p(S-co-AAc) 於生醫材料之應用有其發展潛力。

The goal of this research is to synthesize zwitterionic copolymers by atmospheric pressure plasma. The copolymers of acrylic amide (AAm), acrylic acid (AAc) with sulfobetaine methacrylate (SBMA) to prepare amide-containing p(S-co-AAm) and carbonyl-containing p(S-co-AAc), two types of the zwitterionic copolymers. The synthesized copolymers were applied to modify the surface of the different substrates such that the surface wettability, zeta potential, biocompatibility , and anti-fouling properties were evaluated.
In the first part of this research, free radicals generated by atmospheric pressure plasma jet (APPJ) were used to replace the initiators used in thermal polymerization reactions. FTIR results revealed that the copolymers prepared by APPJ and thermal polymerization possess similar chemical structure. GPC results showed that the molecular weight of the copolymers increased with the number of APPJ scans whereas lower dispersibility was obtained. APPJ scanning can effectively increase the possibility of re-polymerization of the prepolymers with small molecular weight.
In the second part of this research, in order to improve the adhesion problem of the materials, the prepared copolymers were modified on the surface of substrates. To reveal the hydrophilicity properties of p(S-co-AAm), both of APPJ-assisted polymerized and thermal polymerized p(S-co-AAm) were deposited on TCPS substrate. The water contact angles of the surface modified TCPS were reduced from 88˚ to less than 10˚ which showed the superhydrophilic properties of p(S-co-AAm) copolymers. In the results of protein adsorption test, as compared to the unmodified TCPS substrate, the amounts of lysozyme adsorption son surface modified TCPS reduced by 51 % ~ 60 %. On the other hand, the amount of BSA adsorption reduced by 52 % ~ 62 %. In addition, the results of LDH assay showed the p(S-co-AAm) deposited surface still maintain it biocompatibility. For the hydrophilicity confirmation of p(S-co-AAc), glass was used as a substrate for surface modification test. The results of surface modification on glass showed thatthe water contact of p(S-co-AAc) deposited glass reduced from 33˚ to 4˚ ~ 16˚. To verify the relationship between hydrophilicity increasing and antifouling properties improvement, the p(S-co-AAc) deposited glasses were doing the protein adsorption test of lysozyme and BSA. From the results of protein adsorption test, p(S-co-AAc) deposited glass showed the 52% ~ 66% reduction of lysozyme adsorption, and 40% ~ 56% reduction of BSA adsorption as compared to the pristine glass. From those results, the copolymers prepared via APPJ could retain the same chemical functional groups as the copolymers prepared via traditional polymerization method. In addition, the molecular weight of the copolymers could control by APPJ scanning parameters and preparation methods. Furthermore, on the application of the surface modification of the materials, it can effectively increase the anti-fouling properties of the substrates. Therefore, the uses of APPJ to prepare p(S-co-AAm) and p(S-co-AAc) have potentials for future development and application of medical materials.

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