阿魏酸(ferulic acid, 4-hydroxy 3-methoxy cinnamic acid)研究證實具有抗氧化、抗UV、抗癌及降血壓等活性，普遍存在於許多植物中，分子本身para-hydroxyl的結構更增加其抗氧化性，阿魏酸為有效之自由基清除劑，可防止自由基對神經元細胞的攻擊而不損害細胞本身。OMC是目前研究最為廣泛的UVB防曬劑，也是最不易引起過敏之化學防曬劑。本研究選用阿魏酸及4-甲基肉桂酸(4-methoxycinnamic acid)為基質，以Novozym 435酵素催化酯化反應分別進行合成乙基阿魏酸酯(ethyl ferulate)及辛基肉桂酸酯(octyl methoxycinnamate)。目前文獻有關酵素催化合成上述產物的結果僅達低轉化率且反應時間長，本研究尋求最適化的操作條件而在合理反應時間下達到高轉化率。本研究並探討Novozym 435之重複使用性。

Ferulic acid (4-hydroxy 3-methoxy cinnamic acid), which occurred naturally in many plants, has been shown to possess photoprotective, antioxidant, antitumor and hypertensive activities. Octyl methoxycinnamate (OMC) is the most widely used non-allergic sunscreen agent in the market. Most literatures reported low conversion and long reaction time in the syntheses of ethyl ferulate and OMC. In his study, Novozym 435 was selected as the catalyst for the syntheses of ethyl ferulate from ferulic acid and ethanol, and OMC from 4-methoxycinnamic acid and 2-ethyl hexanol. Parameters that affect the conversion of these reactions as well as the reusability of Novozym 435 were systematically investigated.

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