使用噴霧乾燥法成功合成出介孔生物活性玻璃，通過調節P123界面活性劑與H2O2的濃度來觀察晶相結構、表面形貌、比表面積、孔徑、生物活性及細胞活性等性質。在本次研究中，利用變異數分析找出製程參數對BG表面形貌之影響(SD-18A噴霧乾燥機中，空氣流速>進給速率)，並且成功製備出MBG，發現P123界面活性劑的添加量在3.2vol%能夠獲得最高比表面積(160.60±34.49 m2/g)，H2O2則是在濃度達到30vol%時(109.74±7.21 m2/g)。觀察到所有樣品皆具備生物活性，並且研究證實比表面積與生物活性具有一定的關連性。除了在SEM下清晰可見HA生成，XRD與FTIR的結果也表現出該MBG具備更高的生物活性I1/I2 (58S16P為0.42、58S30H為0.56)。同時所有樣品在細胞毒性中也有良好的表現(25%濃度下58S16P為110.7%、58S30H為97.6%)。最後也探討P123與H2O2兩者間MBG的差異性，由於P123具有碳殘留的缺陷，雖與生物活性無明顯關聯，但卻直接降低細胞存活率，這證實殘碳量對細胞的危害(58S20P為95.8%、58S20P-C為79.1%)。

The mesoporous bioactive glass was successfully synthesized by spray drying method, and the properties of crystalline structure, surface morphology, specific surface area, pore size, bioactivity and cellular activity were observed by adjusting the concentration of P123 surfactant and H2O2. In this study, the effect of process parameters on the surface morphology of BG (SD-18A (109.74±7.21 m2/g) at 30 vol%. All samples were observed to be biologically active, and it was confirmed that there was a correlation between specific surface area and biological activity. In addition to HA production clearly visible under SEM, XRD and FTIR results also showed higher bioactivity I1/I2 (0.42 for 58S16P and 0.56 for 58S30H). Also, all samples showed good cytotoxicity (110.7% for 58S16P and 97.6% for 58S30H at 25% concentration). Finally, the difference in MBG between P123 and H2O2 was also investigated. Since P123 has the defect of carbon residue, although not significantly related to biological activity, it directly reduces cell survival, which confirms the harmful effect of carbon residue on cells (95.8% for 58S20P and 79.1% for 58S20P-C).

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