本論文係有關於磁性奈米載體在血液相容性方面之應用研究。主要將海藻酸鈉(Alginate Sodium)固定化在四氧化三鐵(Fe3O4)磁性奈米載體上，探討製備變因、產品特性並分析血液相容性。
關於海藻酸鈉(Alginate Sodium)固定化在Fe3O4磁性奈米載體上之研究，首先以化學共沉法製備出Fe3O4磁性奈米粒子，然後將海藻酸鈉(Alginate Sodium)直接加入，藉鍵合作用共價鍵結在磁性奈米粒子上，形成具有羧酸根和銨根之磁性奈米載體。由TEM、WAXS和SQUID磁量儀分析得知，磁性奈米粒子在共價鍵結海藻酸，其結構和超順磁性並無明顯改變。由FTIR、熱重分析儀(TGA)分析可確認海藻酸利用共價鍵結在磁性奈米粒子上。本研究所得的表面固定化海藻酸銨磁性奈米粒子，有以下幾項性質：(1) 因具有高的比面積且無孔內擴散阻力，可在短時間內吸附人類血清蛋白(HSA)。(2) 能降低凝血因子的活性，延長凝血時間且因具有羧酸根能抑制血小板固定化在磁性粒子上。

This study concerns the applications of nano-sized magnetic carries in blood compatibility. Alginate Sodium was immobilized on Fe3O4 magnetic nanoparticles. So as to investigate the preparation conditions, product properties, and the performances and the analysis in hemocompatibility.
The investigateion begins with adding alginate sodium to Fe3O4 magnetic nanoparticles . The magnetic nanoparticles were found to interact both with Fe2+ and Fe3+ in an ammonia solution , forming carboxyl groups and Ammonium groups of the magnetic carrier when treating under hydrothermal conditions.From the analyses of TEM, WAXS and SQUID magnetism, there is no obvious change in structure and superparamagnetic characteristics of magnetic nanoparticles after binding alginate. The analyses of FTIR, thermogravimetric analysis (TGA) also confirms the binding of alginate to magnetic nanoparticles , suggesting the mechanism of alginate.The magnetic nanoparticles we get, from the investigateion is embodied with following properties : (1) with absence of pore-diffusion resistance and high specific volume,which enable itself to adsorption/desotption HSA was achievable within 10 mins.(2) with carboxyl groups which is unable adhesion of blood platelet in the short time, and in blood hemoglutination time was greatly elongated.

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