顱骨修補的運用經過長時間的演變已發展出多種材料，而鈦金屬薄板即是現今運用於客製化頭顱骨板的修補材料之一。客製化頭顱骨板相較於傳統的顱骨修補術，其使用CAD技術製造的骨板具有優異的外觀效果，且術後併發症也較其它修補材料少，然而文獻提供的製作程序有限，並無法藉此複製骨板。本研究透過患者頭部的X光電腦斷層影像，依據數位化的二維邊界確認與立體重建技術，將患者頭部的骨骼外型以CAD方式呈現，藉此利用對稱特徵來設計顱骨缺損部位的骨板外型，並以鈦金屬薄板為修補材料，經由CAM與CNC製造模具。接續此用油壓機以引伸加工法將鈦板壓制並塑形成骨板的幾何外型，再藉由鑽孔位置勾勒出骨板輪廓予以裁剪，後製的拋光、電解與雷射雕刻後即完成。而製作完成的客製化頭顱骨板能完整覆蓋骨缺損區域，且最外圈螺絲孔皆可被選為螺絲鎖固用的孔位，因此本研究的骨板邊緣界定方法是可被接受的。另外，骨板有不如預期的成形結果，其原因為本研究使用低成本的螺絲鎖固替代壓料板，導致壓料力不足的板料成形之塑性能量相對較少，而骨板的不規則曲面亦使得板料各區的塑性能力相異，在此雙重的不利條件下讓板材的回彈量難以預測。因此為了改善引伸製品的精度，勢必得設計夾治具來加強周圍板料的束縛力，透過材料的應力-應變曲線圖與模具設計之文獻資料的統合，延伸的相關研究為以預拉力法來降低板料到達降伏強度所需的應力，藉此將有助於提高引伸品的精度。

After long-term evolution following cranioplasty, titanium sheet is one of the substances have been used to fill holes in the skull. There has been considerable interest in the production of customised cranial implants for the repair of skull defects. The objective of this study was to develop an design and manufacture of cranioplasty implants with high anatomical fitness. Firstly, we design with CT scanning data through image thresholding and voxel connectivity. After segmentation the bone surface contours are mathematically modeled using triangles or polygons to create a mesh and converted in a suitable Computer Aided Design file format. A non-defected part from contra-lateral side of skull is mirrored based on the imaging technique for designing implants. The titanium sheet is forming into the implant mold, drilled on the periphery, cut to shape, electropolished, and tabbed. The boned damage region may be covered by the finished cranioplasty plates, and the hole on the periphery can be locked for screws. Hence, the method of edge definition is to be accepted. In addition, it is unintended forming in cranioplasty plates, so the future we impose pre-tension on titanium sheet to reduce the yield strength by integrating the stress-strain curve into the mold design, it can enhance the plastic ability of the material and raise forming accuracy.

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