本研究目的首要建立股骨實體模型重建的標準程序，以及使用腫瘤系列之人工關節植入股骨之有限元素分析流程。藉由醫學影像、電腦輔助設計及有限元素分析軟體，建立兩部分的模型，第一為幾何模型，其中包含三維股骨視覺模型、三維股骨輪廓模型、三維股骨實體模型及人工關節植入股骨之三維實體模型；第二為有限元素分析模型。針對人工關節植入股骨及臨床醫學上常發生的病例，進行生物力學有限元素分析，假設人在單腳站立時髖關節受力的狀態，探討比較股骨材料性質之均質性與正交性、人工關節植入股骨、比較植入人工關節之截骨長度比率、比較10組病例之應力分析差異及股骨遭骨腫瘤破壞。根據本研究分析結果顯示，截骨長度不宜過度極端，其截骨長度比率40 %∼50 % 於密質骨之應力分佈較為平均；比較10組病例之應力分析，若病患骨幹愈粗，愈能夠承受負荷；若病患骨幹曲率愈大，容易造成彎矩應力增大；當骨腫瘤罹患位置於近端股骨或中端股骨，假設骨腫瘤為圓柱形，直徑達20 mm時已影響股骨結構強度，此時宜置換腫瘤系列之人工關節。依據本研究發展之流程及分析結果，可提供訊息協助醫師於臨床的診斷及治療。

This research is to establish a procedure of reconstructing femur solid model for FEA of prosthesis implantation of femur in oncology system. With softwares of medical image, CAD and FEA, the geometry model includes bone-visual model (BVM), bone-contour model (BCM), bone-solid model (BSM) and bone-prosthesis model (BPM) have been constructed. Mesh model for FEA has also been implemented to investigate the amputation limb ratio and effects of bone tumor. Material of isotropic and orthotropic property for cortical bone of femur have been considered in EFA. Then the amputation limb ratio by implantation prosthesis and comparison of 10 cases for stress analysis have been performed. The effects of size and location of bone tumor in femur have been analyzed with stress analysis. Results show that the amputation limb ratio is suggested to be within 40 % ~ 50 % because the maximum von Mises stress of cortical bone distributes more uniformly. Comparisons of stress analysis results of 10 cases of proximal BPM, the thicker the femur diaphysis is, the higher loading it can be sustained. The larger curvature of the femur diaphysis is, the higher bending stress occurs. If the bone tumor locates on the proximal femur or medial femur, the maximum von Mises stress increases significantly as the diameter of bone tumor reaches 20 mm. Therefore, it is recommended to replace the prosthesis of oncology system. Results of the developed BPM and FEA are expected to provide clinical information for diagnosis and therapy.

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