研究生: |
蔡憲鋒 Hsien-feng Tsai |
---|---|
論文名稱: |
合成具有控制藥物釋放速率之新藥物載體:中孔洞生物活性玻璃-乙烯基三甲氧基矽烷 Synthesis of a new drug carrier controlling drug release rate: Mesoporous bioactivity glasses-Vinyltrimethoxysilane (MBGs-VS) |
指導教授: |
徐新光
Shin-Guang Shyu 朱瑾 Jinn Chu |
口試委員: |
林秀美
none 張一知 none |
學位類別: |
碩士 Master |
系所名稱: |
應用科技學院 - 應用科技研究所 Graduate Institute of Applied Science and Technology |
論文出版年: | 2011 |
畢業學年度: | 99 |
語文別: | 中文 |
論文頁數: | 47 |
中文關鍵詞: | 中孔生物活性玻璃 、藥物遞送系統 、官能化 、布洛芬 、乙烯基三甲氧基矽烷 |
外文關鍵詞: | Mesoporous bioactive glass, drug-delivery systems, functionalization, Ibuprofen, Vinyltrimethoxysilane |
相關次數: | 點閱:298 下載:3 |
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中孔矽材料近年來發展迅速,其具穩定且一致的中孔結構、高表面積、可調整的狹小尺寸分布、明確且可修飾的表面性質、無毒性與好的生物相容性等特點,這些特點也使得中孔矽材料在生醫材料上有著很好的應用性。
中孔生物活性玻璃(mesoporous bioactivity glasses,MBGs)於2005年被發表出來,此材料將中孔洞材料與生物活性玻璃(bioactivity glasses,BGs)做結合,因其更容易於骨組織中產生氫氧基磷灰石(hydroxyapatite,HA),因此較一般中孔矽材料有更高的生物活性,在做為藥物遞送系統方面,其壁上矽醇基團可進行官能化反應,達到控制藥物釋放速率的效果,以上特點皆是中孔洞生物活性玻璃做為骨修復材料重要的條件。
本篇以Ibuprofen做為載入藥物,以Vinyltrimethoxysilane(VS)為封口劑進行表面官能化反應,研究不同VS添加量與藥物釋放速率的關係,探討此材料在人體藥物治療上是否為一適合載體。
Mesoporous silica materials have been developed rapidly in recent years in that these materials have several newly-found advantages, namely, the steady, uniform mesoporous structure, high surface area, adjustable narrow distribution of pore sizes, easily- modified surface properties, non-toxicity and good biocompatibility. These characteristics equip the mesoporous silica materials with very good applications of biomedical materials.
Mesoporous bioactive glass was published in 2005. This material combined mesoporous material with bioactive glasses, making it easier to form Hydroxyapatite in bone tissue. Therefore, the bioactivity is higher than common mesoporous silicon materials. As a drug delivery system, the walls silanol groups can be functionalized to achieve the aim of controlling drug release rate. The characteristics described above are all important conditions for mesoporous bioactive glasses to be used as bone repair materials.
This project employs the medicine, ibuprofen, as guest molecules to store and Vinyltrimethoxysilane for the sealant to be utilized into the surface functionalization reactions. Studying the different relationships between altering the amount of Vinyltrimethoxysilane and its effect on the drug release rate can provide more supporting ideas to discuss if they can be proper carriers in body therapy.
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