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| 研究生： |
葉俊緯 Jun-Wei Ye |
|---|---|
| 論文名稱： |
使用視覺刺激的方式來探討fMRS在3T磁振造影系統下的可行性 Feasibility of fMRS using visual stimulation at 3T MR system |
| 指導教授： |
林益如
Yi-Ru Lin |
| 口試委員: |
黃騰毅
Teng-Yi Huang 劉益瑞 Yi-Jui Liu 林益如 Yi-Ru Lin 蔡尚岳 Shang-Yueh Tsai |
| 學位類別： |
碩士 Master |
| 系所名稱： |
電資學院 - 電子工程系 Department of Electronic and Computer Engineering |
| 論文出版年： | 2018 |
| 畢業學年度： | 106 |
| 語文別： | 英文 |
| 論文頁數： | 36 |
| 中文關鍵詞： | 功能性磁共振頻譜 、3T儀器 、視覺刺激 、初級視覺區 |
| 外文關鍵詞： | fMRS, 3T system, visual stimulation, primary visual cortex |
| 相關次數： | 點閱：328 下載：1 |
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磁共振頻譜 (MRS)提供一種非侵入性的技術來觀測大腦內存在哪些代謝物以及這些代謝物濃度的多寡是否正常，藉由了解這些訊息來幫助診斷病因。功能性磁共振頻譜 (fMRS)則是透過讓大腦接受外在刺激後，觀察特定腦區進行神經活動時的代謝物濃度變化。有幾篇關於腦部視覺皮質區的fMRS研究指出，在7T磁場強度的MRI儀器下，讓大腦接受視覺刺激可以觀察到代謝物濃度有顯著的改變，尤其是谷氨酸(Glutamate)、乳酸(Lactate)，變化量達到2%以及17%。本研究目的在3T磁場強度下，觀察大腦視覺區在接受到視覺刺激時代謝物的濃度變化，藉此探討fMRS在3T的可行性。此研究的視覺刺激包含3次黑底白十字的圖片以及2次棋盤格閃爍，VOI擺放在初級視覺區 (Primary visual cortex,VC1)，總共視覺刺激時間約為10分鐘。初步的分析顯示，視覺區的血氧濃度相依對比 (Blood-oxygen-level dependent, BOLD)有明顯變化，但是代謝物的濃度在接受視覺刺激時沒有發現顯著的變化。此現象可能與VOI的擺放位置有關，如果能夠更精確地得知有反應的區域，fMRS在3T仍有機會可以觀察到代謝物濃度變化。
Functional magnetic resonance spectroscopy has been used to observe brain metabolism during physical stimulation in a non-invasive way. Recent researches have indicated that metabolic concentration changed during visual and motor stimuli using fMRS at 7T system. These studies also showed that glutamate (Glu) and lactate (Lac) have been found to increase by 2% and 17% during stimuli using block design in experiments. The main purpose is to find out the potential of fMRS at 3T system by observing the metabolic change during visual stimulation. Three blocks of black background image and two blocks of flashing checkerboard were interleaved as stimuli material and voxel was located at primary visual cortex. The total fMRS experiment time was about 10 minutes. Our preliminary results showed that concentration of metabolites did not have significant change. But BOLD contrast changed during activation periods. This phenomenon might be related to the placement of VOI. It is possible to observe the metabolic change using fMRS at 3T system if the VOI can be positioned more precisely according to really reactive area.
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