本研究主要以開發可見光固化口腔贋復體樹脂，以強化樹脂特性及符合生物相容性為主軸並應用於3D列印，成功合成同時具有所有口腔贋復體所兼具特性的可見光固化口腔贋復體樹脂。
首先以樹脂之主要關鍵材料–光起始劑之特性研究開始，鑒於乙基咔唑硫雜蔥酮 (Thioxanthone-Ethylcarbazole, TX-EC) 在可見區具有優異的吸收特性，其最大波長接近450 nm且延伸至475 nm，先透過優化及簡化合成步驟製備出大量的TX-EC，接著分別以不同數量的官能基樹脂單體交互搭配，藉由固定參數，進行光反應動力學分析及尺寸精準度測試，由TX-EC (1 %) 搭配三官能基單體 VFC_3DV1 (3D) 可以獲得最佳的光聚合轉化率及尺寸精準度。
考量牙科應用情境，對於口腔贋復體材料有機械、物理等性質特性的要求接著以甲基丙烯酸三氟乙酯 (Trifluoroethyl methacrylate) 進行樹脂韌性強化，藉由FTIR、三點彎曲測試以及接觸角測試結果得知在添加量29 wt% (氟含量0.1 wt%)中有最佳結果。延續上述結果將二氧化鋯奈米顆粒作為填料添加在稀釋後的樹脂以增加其在機械強在度上的表現，透過探討二氧化鋯在樹脂裡的分散性、色度、維克氏硬度機與旋轉磨耗測試，40 wt%的二氧化鋯整體複合材料有最佳表現。
最後以小鼠雜交瘤細胞 (7F2 Cell) 作為欲培養之細胞測試生物相容性，並與培養品標準品材料 (Tissue culture polystyrene, TCPS) 以及商用口腔贋復樹脂TEMPRON的生物相容性做比較，最後結果顯示本研究欲開發之可見光固化口腔贋復體樹脂有極度良好的生物相容性，具備於口腔贋復體應用的潛力。

The work is to develop visible light photo-curing resin for dental applications by additive manufacturing, where the main challenges are to improve mechanical properties and biocompatibility of the resin formulation. After a series of synthetic steps and material modifications, the physical, chemical and mechanical properties of photo-curable resin has been verified and compared against a commonly available commercial one.
Thioxanthone-Ethylcarbazole, as known as the photoinitiator, has a quite good absorption property the in visible light region, with the maximum wavelength ranging from 450 nm to 475 nm. The original synthetic steps of TX-EC have been simplified with improved yield. It was followed polymerization testing by mixing several types of monomers with various mutli-functional group and different percentage of TX-EC. The kinetics of the photopolymerization reaction and shrinkage test were the major concerns. These results showed that 3-functional groups monomer mixed with 1 wt% photoinitiator (VFC_3DV1 (3D) TX-EC) could produce cured resin with the highest conversion and dimensional accuracy within realistic light exposure time.
Considering the practical requirements of dental or orthodontic materials on materials, trifluoroethyl methacrylate was selected as the surface modifying agent to optimize the fracture toughness. In addition, by taking advantages of unique property of fluorine, it was also envisaged to include the self-cleaning effect into the resin after modification. After FTIR measurement, three point bending and contact angle tests, the result showed that 29 wt% of trifluoroethyl methacrylate ( 0.1 wt% of Fluorine content) could produce the best result. Next, zirconium dioxide nanoparticles were applied as a filler and reinforce the mechanical properties of the composite resin. By studying the mixing effect, chromaticity coordinates, spectrophotometer, Vickers hardness test and rotary abrasive test, it was found that addition of 40 wt% Zirconium dioxide was able to achieve the optimum results.
Ultimately, biocompatibility test was conducted. 7F2 cells were cultured in the wells containing standard tissue culture polystyrene (TCPS) , commercial temporary denture resin and the resin composite in final composition, respectively. From the results, the developed resin (3DF_Zr) in this study has surpassed the counterparts and demonstrated excellent bio-compatibility. The developed resin formulation has shown great potential for dental application, especially the fabrication of customized prostheses by additive manufacturing.

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