本論文結合了奈米合成技術與生物醫學應用，將低毒性之量子點應用於細胞體上，作為顯影標靶與藥物載體之功能。第一部分的實驗主要是以水為溶劑來合成Zn-CuInS2 (ZCIS)量子點，並藉由優化Cu、In與Zn等前驅物比例，提高量子點之量子產率，以及使用雙穩定劑穀胱甘肽與聚丙烯酸鈉來使量子點能夠在水中穩定地合成出來；接著將核層量子點以無機材料ZnS包覆而形成核殼型量子點ZCIS/ZnS，可明顯提高量子點的螢光量子產率至16.8%，並利用穿透式電子顯微鏡、X光繞射儀與螢光光譜儀來進行量子點組成、結構、光學性質之分析。第二部分則是將量子點功能化，使用胺基苯硼酸修飾於量子點表面，提高量子點之生物相容性，並以共軛焦距顯微鏡偵測材料於Hela細胞體內之顯影效果。最後則是將功能化之量子點作為奈米藥物載體，利用抗癌藥物DOX與量子點中Zn2+離子之配位關係，將DOX裝載於量子點上，並於癌細胞之酸性環境中釋放出DOX，以達到抑制癌細胞之效果。

In this research, we investigate the synthesis process of quantum dots and its biomedical applications on cell imaging along with delivering anticancer drug. In the beginning, we directly synthesize water-soluble Zn-CuInS2 quantum dots (ZCIS QDs) facilitated by polyacrylic acid and L-glutathione as stabilizing and reactivity-controlling agents. The optimization of copper, indium and zinc ratio to improve the quantum yields of ZCIS QDs also become important part to be improved on this research. Moreover, by ZnS coating on the surface of ZCIS QDs, the quantum yield value can be increased significantly to 16.8%. We further conjugate 3-aminophenylboronicacid as cancer targeting agents onto ZCIS/ZnS QDs via formation the cyclic boronate ester with sialic acid on the membrane of cell. Beside evaluate its imaging potential with confocal microscopy, the competence of ZCIS/ZnS QDs as platform for targeted and pH responsive intracellular delivery of an anticancer drug also improved. Therefore, Doxorubicin is loaded onto the APBA functionalized ZCIS/ZnS QDs by formation of metal complexes with Zn2+ on the QDs. The conjugation of DOX on ZCIS/ZnS@APBA QDs can be maintained at physiological condition, but directly break in the mildly acidic condition like on intracellular environment of cancer cells. Hence, this approach can provide nanovector-based material as simultaneous targeting and therapy of cancer cells.

[1] J. Zhang, R. G. Xie and W. S. Yang, Chem. Mater., 2011, 23, 3357.
[2] S. Sarkar, N. S. Karan and N. Pradhan, Angew. Chem., Int. Ed., 2011, 50, 6065.
[3] J. Feng, M. Sun, F. Yang and X. R. Yang, Chem. Commun.,2011, 47, 6422.
[4] E. Cassette, T. Pons, C. Bouet, M. Helle, L. Bezdetnaya,F. Marchal and B. Dubertret, Chem. Mater., 2010, 22, 6117.
[5] G. Manna, S. Jana, R. Bose and N. Pradhan, J. Phys. Chem. Lett., 2012, 3, 2528.
[6] 羅吉宗編撰，奈米科技導論，全華圖書股份有限公司，台灣
[7] G. Sun,The Intersubband Approach to Si-based Lasers,Advances in Lasers and Electro Optics,Nelson Costa and Adolfo Cartaxo (Ed.), 2010.
[8] A. P. Alivisatos, Science, 1996, 271, 933.
[9] Chemical Education Journal (CEJ), Vol. 13, No. 2, 2009.
[10] R. Kubo, J. Phys. Soc. jpn., 1962, 17, 975.
[11] X. Peng, L. Manna, W. Yang, J. Wickham, E. C. Scher, A. Kadavanich, A. P. Alivisatos, Nature, 2000, 404, 59.
[12] R. Rossetti, S. Nakahara, and L. E. Brus, J. Chem. Phys., 1983, 79, 1086.
[13] C. B. Murray, D. J. Noms, and M. G. Bawendi, J. Am. Chem. Soc., 1993, 115, 8706.
[14] A. Mews, A. Eychmiiller, M. Giersig, D. Schooss, and H. Weller, J. Phys. Chem., 1994, 98, 934.
[15] W. T. Wu, T. Zhou, A. Berliner, P. Banerjee and S. Q. Zhou, Angew. Chem. Int. Ed., 2010, 49, 1.
[16] Q. Ma, E. Ha, F. P. Yang and X. G. Su, Anal. Chim. Acta, 2011, 701, 60.
[17] Y. Gao, H. Huang, J. J. Hu, S. M. Shah and X. G. Su, Talanta,2011, 85, 1075.
[18] S. Liu, F. Shi, L. Chen and X. Su, Analyst, 2013, 138, 5819.
[19] S. Liu, F. Shi, L. Chen and X. Su, Talanta, 2013, 116, 870.
[20] P. O. Anikeeva, J. E. Halpert, M. G. Bawendi and V. Bulović, Nano Letters, 2009, 9, 2532.
[21] http://www.qled-info.com/introduction/ , 2014/4/23.
[22] S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi and J. V. Frangioni, Nat. Biotechnol., 2004, 22, 93.
[23] J. Thomas, D. B. Sherman, T. J. Amiss, S. A. Andaluz and J. B. Pitner, Bioconjugate Chem., 2007, 18, 1841.
[24] S. K. Vashist, R. Tewari, R. P. Bajpai, L. M. Bharadwaj and R. Raiteri, azonano, 2006.
[25] S. Mishra, STRUCTURAL, ELECTRONIC AND OPTICALPROPERTIES OF CHALCOPYRITE TYPESEMICONDUCTORS, Thesis, 2012.
[26] P. M. Allen and M. G. Bawendi, J. Am. Chem. Soc., 2008, 130, 9240.
[27] R. G. Xie, M. Rutherford and X. G. Peng, J. Am. Chem. Soc.,2009, 131, 5691
[28] J. Park and S. W. Kim, J. Mater. Chem., 2011, 21, 3745
[29] J. Y. Chang, G. Q. Wang, C. Y. Cheng, W. X. Lin and J. C. Hsu, J. Mater. Chem., 2012, 22, 10609.
[30] B. K. Chen, H. Z. Zhong and B. S. Zou, Prog. Chem., 2011, 23, 2276.
[31] X. Yuan, J. L. Zhao, P. T. Jing, W. J. Zhang, H. B. Li, L. G. Zhang, X. H. Zhong and Y. Masumoto, J. Phys. Chem. C, 2012, 116, 11973.
[32] M. Kruszynska, H. Borchert, J. Parisi and J. Kolny-Olesiak, J. Am. Chem. Soc., 2010,132, 15976.
[33] X. L. Wang, D. C. Pan, D. Weng, C. Y. Low, L. Rice, J. Y. Han and Y. F. Lu, J. Phys. Chem. C, 2010, 114, 17293.
[34] D. C. Pan, X. L. Wang, Z. H. Zhou, W. Chen, C. L. Xu and Y. F. Lu, Chem. Mater., 2009, 21, 2489.
[35] P. C. Dai, X. N. Shen, Z. J. Lin, Z. Y. Feng, H. Xu and J. H. Zhan, Chem. Commun., 2010, 46, 5749.
[36] Q. H. Liu, Z. C. Zhao, Y. H. Lin, P. Guo, S. J. Li, D. C. Pan and X. L. Ji, Chem. Commun., 2011, 47, 964.
[37] K. T. Yong, I. Roy, R. Hu, H. Ding, H. X. Cai, J. Zhu, X. H. Zhang, E. J. Bergey and P. N. Prasad, Integr. Biol., 2010, 2, 121.
[38] T. Pons, E. Pic, N. Lequeux, E. Cassette, L. Bezdetnaya, F. Guillemin, F.Marchal and B. Dubertret, ACS Nano, 2010, 4, 2531.
[39] T. Omata, K. Nose, and S. Otsuka-Yao-Matsuo, J. Appl. Phys., 2009, 105, 073106..
[40] Y. Jiang, Y. Wu, X. Mo, W. Yu, Y. Xie and Y. Qian, Inorg. Chem., 2000, 39, 2964.
[41] S. L. Castro, S. G. Bailey, R. P. Raffaelle, K. K. Banger and A. F. Hepp, J. Phys. Chem. B, 2004, 108, 12429.
[42] L. Tian, H. I. Elim, W. Ji and J. J. Vittal, Chem. Commun., 2006, 4276.
[43] L. Tian, J. J. Vittal, New J. Chem., 2007, 31, 2083.
[44] T. Torimoto, T. Adachi, K. Okazaki, M. Sakuraoka,T. Shibayama, B. Ohtani, A. Kudo and S. Kuwabata, J. Am. Chem. Soc., 2007, 129, 12388.
[45] T. Torimoto, S. Ogawa, T. Adachi, T. Kameyama, K. Okazaki, T. Shibayama, A. Kudo and S. Kuwabata, Chem. Commun., 2010, 46, 2082.
[46] T Ogawa, T Kuzuya, Y. Hamanaka and K. Sumiyama, J. Mater. Chem., 2010, 20, 2226.
[47] J. Y Chang, G. Q. Wang, C. Y. Cheng, W. X. Lin and J. C. Hsu, J. Mater. Chem., 2012, 22, 10609.
[48] W. Zhang and X. Zhong, Inorg. Chem., 2011, 50, 4065.
[49] X. Tang, W. Cheng, E. S. G. Choo and J. Xue, Chem. Commun., 2011, 47, 5217.
[50] N. Chan. W. Guo, Y. Tu, C. Dong, B. Zhang, C. Hu and J. Chang, Theranostics, 2013, 3, 99.
[51] S. Liu, H. Zhang, Y. Qiao and X. Su, RSC Advances, 2012, 2, 819.
[52] Z. Luo, H. Zhang, J. Huang and X. Zhong, Journal of Colloid and Interface Science, 2012, 377, 27.
[53] Y. Chen, S. Li, L. Huang and D. Pan, Nanoscale, 2014, 6, 1295.
[54] K.-K. Song, S. Lee, Curr. Appl. Phys., 2001, 1, 169.
[55] M. J. Murcia, D. L. Shaw, E. C. Long, and C. A. Naumann, Opt. Commun., 2008, 7, 1771.
[56] D. V. Talapin, A. L. Rogach, A. Kornowski, M. Haase, and H. Weller, Nano Lett., 2001, 1, 207.
[57] S. F. Wuister, C. de Mello Donegá and A. Meijerink, J. Phys. Chem. B, 2004, 108, 17393.
[58] X. H. Zhong, Y. Y. Feng, W. Knoll, M. Y. Han, J. Am. Chem. Soc., 2003, 125, 13559.
[59] M. D. Regulacio and M.-Y. Han, Accounts Chem. Res., 2010, 43, 621.
[60] H. Nakamura, W. Kato, M. Uehara, K. Nose, T. Omata, S. Otsuka-Yao-Matsuo, M. Miyazaki and H. Maeda, Chem. Mater., 2006, 18, 3330.
[61] B. O. Dabbousi, J. Rodriguez-Viejo, F. V. Mikulec, J. R. Heine, H. Mattoussi, R. Ober, K. F. Jensen and M. G. Bawendi, J. Phys. Chem. B, 1997, 101, 9463.
[62] X. Peng, M. C. Schlamp, A. V. Kadavanich, and A. P. Alivisatos, J. Am. Chem. Soc.,1997, 119, 7019.
[63] P. Reiss, J. Bleuse, and A. Pron, Nano Lett., 2012, 2, 781.
[64] D. V. Talapin, I. Mekis, S. Gotzinger, A. Kornowski, O. Benson, H. Weller, J. Phys. Chem. B, 2004, 108, 18826.
[65] Y. Chen, S. Li, L. Huang, and D. Pan, Inorganic Chemistry, 2013, 52, 7819.
[66] L. Li, A. Pandey, D. J. Werder, B. P. Khanal, J. M. Pietryga, and Vi. I. Klimov, J. Am. Chem. Soc., 2010, 133, 1176.
[67] D. C. Pan, L. J. An, Z. M. Sun, W. Hou, Y. Yang, Z. Z. Yang and Y. F Lu, J. Am. Chem. Soc. , 2008, 130, 5620.
[68] Q. Liu, Z. Zhao, Y. Lin, P. Guo, S. Li, D. Pan and X. Ji, Chem. Commun. , 2011, 47, 964.
[69] P. Reiss, M. Protiere, and L. Li, Small, 2009, 5, 154..
[70] A. G. Tkachenko, H. Xie, D. Coleman, W. Glomm, J. Ryan, M. F. Anderson, S. Franzen, and D. L. Feldheim, J. Am. Chem. Soc., 2003, 125, 4700.
[71] B. C. Lagerholm, M. M. Wang, L. A. Ernst, D. H. Ly, H. J. Liu, M. P. Bruchez and A. S. Waggoner, Nano Lett., 2004, 4, 2019.
[72] B. R. Liu , Y. W. Huang , J. G. Winiarz , H. J. Chiang and H. J. Lee, Biomaterials,2011, 32, 3520.
[73] Y. Yoneda, M. Hieda, E. Nagoshi, and Y. Miyamoto, Cell Struct. Funct., 1999, 24, 425.
[74] F. Chen and D. Gerion, Nano Lett., 2004, 4, 1827.
[75] T. Pellegrino, W. J. Parak, R. Boudreau, M. A. L. Gros, D. Gerion, A. P. Alivisatos and C. A. Larabell, Differentiation, 2003, 71, 542.
[76] W. J. Parak, R. Boudreau, M. L. Gros, D. Gerion, D. Zanchet, C. M. Micheel, S. C. Williams, A. P. Alivisatos and C. Larabell, Adv. Mater., 2002, 14, 882.
[77] K. Hanaki, A. Momo, T. Oku, A. Komoto, S. Maenosono, Y. Yamaguchi and K. Yamamoto, Biochem. Biophys. Res. Commun., 2003, 302, 496.
[78] Q. Wang, F. Ye, T. Fang, W. Niu, P. Liu, X. Min, X. Li, Journal of Colloid and Interface Science, 2011, 35, 9.
[79] Conjugate comprising a folic acid antagonist and a carrier , United States Patent 6720304.
[80] D. J. Bharali, D. W. Lucey, H. Jayakumar, H. E. Pudavar, and P. N. Prasad, J. Am. Chem. Soc., 2005, 127, 11364.
[81] A. Liu, S. Peng, J. C. Soo, M. Kuang, P. Chen, and H. Duan, Analytical Chemistry, 2011, 83, 1124.
[82] W. Zhang, X. W. He, Y. Q. Yang, W.Y. Li and Y. K Zhang, J. Mater. Chem. B, 2013, 1, 347.
[83] R. Hardman, Environmental Health Perspectives, 2006, 114, 165.
[84] N. Chen, Y. He, Y. Su, X. Li, Q. Huang, H. Wang, X. Zhang, R. Tai and C. Fan, Biomaterials, 2012, 33, 1238.
[85] M. Bottrill and M. Green, Chem. Commun., 2011, 47, 7039.
[86] K. T. Yong, W. C. Law, R. Hu, L. Ye, L. Liu, M. T. Swihart and P. N. Prasad, Chem. Soc. Rev., 2013, 42, 1236.
[87] A. M. Derfus, W. C. W. Chan, and S. N. Bhatia, Nano Lett., 2004, 4, 11.
[88] J. Lovic, H. S. Bazzi, Y. Cuie, G. R. A. Fortin, F. M. Winnik, D. Maysinger, J Mol Med, 2005, 82, 377.
[89] T. S. Hauck, R. E. Anderson, H. C. Fischer, S. Newbigging, and W. C. W. Chan, Small, 2010, 6, 138.
[90] I. L. Medintz, A. R. Clapp, H. Mattoussi, E. R. Goldman, B. Fisher and J. M. Mauro, Nat. Mater., 2003, 2, 630.
[91] E. Oh, M. Y. Hong, D. Lee, S. H. Nam, H. C. Yoon and H. S. Kim, J. Am. Chem. Soc., 2005, 127, 3270.
[92] R. Alam, J. Zylstra, D. M. Fontaine, B. R. Branchini and M. M. Maye, Nanoscale, 2013, 5, 5303.
[93] D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit and R. Langer, Nat. Nanotechnol., 2007, 2, 751.
[94] R. A. Petros and J. M. De Simone, Nat. Rev. Drug Discovery, 2010, 9, 615.
[95] M. De, P. S. Ghosh and V. M. Rotello, Adv. Mater., 2008, 20, 4225.
[96] Y. Cheng, A. C. Samia, J. D. Meyers, I. Panagopoulos, B. Fei and C. Burda, J. Am. Chem. Soc., 2008, 130, 10643.
[97] S. H. Medina and M. E. H. El-Sayed, Chem. Rev., 2009, 109, 3141.
[98] T. L. Doane and C. Burda, Chem. Soc. Rev., 2012, 41, 2885.
[99] Y. Bae, N. Nishiyama, S. Fukushima, H. Koyama, M. Yasuhiro and K. Kataoka, Bioconjugate Chem., 2005, 16, 122.
[100] G. Helmlinger, F. Yuan, M. Dellian and R. K. Jain, Nat. Med., 1997, 3, 177.
[101] S. Angelos, N. M. Khashab, Y.-W. Yang, A. Trabolsi, H. A. Khatib, J. F. Stoddart and J. I. Zink, J. Am. Chem. Soc., 2009, 131, 12912.
[102] N. M. Khashab, M. E. Belowich, A. Trabolsi, D. C. Friedman, C. Valente, Y. Lau, H. A. Khatib, J. I. Zink and J. F. Stoddart, Chem. Commun., 2009, 5371.
[103] L. Du, S. Liao, H. A. Khatib, J. F. Stoddart and J. I. Zink, J. Am. Chem. Soc., 2009, 131, 15136.
[104] F. Muhammad, M. Guo, W. Qi, F. Sun, A. Wang, Y. Guo and G. Zhu, J. Am. Chem. Soc., 2011, 133, 8778.
[105] X. Zhang, L. Meng, Q. Lu, Z. Fei and P. J. Dyson, Biomaterials, 2009, 30, 6041.
[106] H. Meng, M. Liong, T. Xia, Z. Li, Z. Ji, J. I. Zink and A. E. Nel, ACS Nano, 2010, 4, 4539.
[107] X. Zhang, L. Clime, H. Roberge, F. Normandin, L. Yahia, E. Sacher and T. Veres, J. Phys. Chem. C, 2011, 115, 1436.
[108] D. Pornpattananangkul, S. Olson, S. Aryal, M. Sartor, C.-M. Huang, K. Vecchio and L. Zhang, ACS Nano, 2010, 4, 1935.
[109] S. Dhar, W. L. Daniel, D. A. Giljohann, C. A. Mirkin and S. J. Lippard, J. Am. Chem. Soc., 2009, 131, 14652.
[110] M. Bikram and J. L. West, Expert Opin. Drug Delivery, 2008, 5, 1077.
[111] L. E. Strong and J. L. West, Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol., 2011, 3, 307.
[112] S. R. Sershen, S. L. Westcott, N. J. Halas and J. L. West, J. Biomed. Mater. Res., 2000, 51, 293.
[113] J. Raula, J. Shan, M. Nuopponen, A. Niskanen, H. Jiang, E. I. Kauppinen and H. Tenhu, Langmuir, 2003, 19, 3499.
[114] J. Guo, W. Yang, Y. Deng, C. Wang and S. Fu, Small, 2005, 1, 737.
[115] T. Fujigaya, T. Morimoto, Y. Niidome and N. Nakashima, Adv. Mater., 2008, 20, 3610.
[116] H. Takahashi, Y. Niidome and S. Yamada, Chem. Commun., 2005, 2247.
[117] J. M. Slocik, F. Tam, N. J. Halas and R. R. Naik, Nano Lett., 2007, 7, 1054.
[118] B. Duncan, C. Kim and V. M. Rotello, J. Controlled Release, 2010, 148, 122.
[119] K. Patel, S. Angelos, W. R. Dichtel, A. Coskun, Y. W. Yang, J. I. Zink and J. F. Stoddart, J. Am. Chem. Soc., 2008, 130, 2382.
[120] J. Jung, A. Solanki, K. A. Memoli, K.-I. Kamei, H. Kim, M. A. Drahl, L. J. Williams, H.-R. Tseng and K.-B. Lee, Angew. Chem., Int. Ed., 2010, 49, 103.
[121] M. E. Akerman, W. C. W. Chan, P. Laakkonen, S. N. Bhatia and E. Ruoslahti, Proc. Natl. Acad. Sci. U. S. A., 2002, 99, 12617.
[122] H. M. Xiong, Y. Xu, Q. G. Ren and Y. Y. Xia, J. Am. Chem. Soc., 2008, 130, 7522.
[123] K. T. Yong, H. Ding, I. Roy, W. C. Law, E. J. Bergey, A. Maitra and P. N. Prasad, ACS Nano, 2009, 3, 502.
[124] B. Mao, C.-H. Chuang, J. Wang and C. Burda, J. Phys. Chem. C, 2011, 115, 8945.
[125] S. Zhu, J. Zhang, C. Qiao, S. Tang, Y. Li, W. Yuan, B. Li, L. Tian, F. Liu, R. Hu, H. Gao, H. Wei, H. Zhang, H. Sun and B. Yang, Chem. Commun., 2011, 47, 6858.
[126] K. T. Yong, H. Ding, I. Roy, W. C. Law, E. J. Bergey, A. Maitra and P. N. Prasad, ACS Nano, 2009, 3, 502.
[127] S. Hu and L. H. V. Wang, J. Biomed. Opt., 2010, 15, 011101.
[128] C. Kim, C. Favazza and L. V. Wang, Chem. Rev., 2010, 110, 2756.
[129] V. Ntziachristos, Nat. Methods, 2010, 7, 603.
[130] D. Graham-Rowe, Nat. Photonics, 2009, 3, 123.
[131] Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica and L. V. Wang, Nano Lett., 2004, 4, 1689.
[132] Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan and S. Emelianov, Nano Lett., 2011, 11, 348.
[133] C. Kim, C. Favazza and L. V. Wang, Chem. Rev., 2010, 110, 2756.
[134] Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica and L. V. Wang, Nano Lett., 2004, 4, 1689.
[135] H. F. Zhang, K. Maslov, G. Stoica and L. V. Wang, Nat. Biotechnol., 2006, 24, 848.
[136] A. Agarwal, S. W. Huang, M. O’Donnell, K. C. Day, M. Day, N. Kotov and S. Ashkenazi, J. Appl. Phys., 2007, 102, 064701.
[137] D. E. J. G. J. Dolmans, D. Fukumura and R. K. Jain, Nat. Rev. Cancer, 2003, 3, 380.
[138] J. P. Celli, B. Q. Spring, I. Rizvi, C. L. Evans, K. S. Samkoe, S. Verma, B. W. Pogue and T. Hasan, Chem. Rev., 2010, 110, 2795.
[139] Y. Cheng and C. Burda, in Comprehensive Nanoscience and Technology, ed. D. L. Andrews, G. D. Scholes and G. P. Wiederrecht, Academic Press, Oxford, 2011, vol. 2, ch. 2.01 Nanoparticles For Photodynamic Therapy, pp. 1.
[140] W. J. Syu, H. P. Yu, C. Y. Hsu, Y. C. Rajan, Y. H. Hsu ,Y. C. Chang , W. Y. Hsieh, C. H. Wang and P. S. Lai, Small, 2012, 8, 2060.
[141] J.-Y. Chen, Y.-M. Lee, D. Zhao, N.-K. Mak, R. N.-S. Wong, W.-H. Chan and N.-H. Cheung, Photochem. Photobiol., 2010, 86, 431.
[142] A. Rakovich, D. Savateeva, T. Rakovich, J. F. Donegan, Y. P. Rakovich, V. Kelly, V. Lesnyak and A. Eychmu‥ ller, Nanoscale Res. Lett., 2010, 5, 753.
[143] A. Rockett and R. W. Birkmire., J. Apply Phys, 1991, 70, R81.
[144] K. Nose, T. Omata and S. Otsuka-Yao-Matsuo, J. Phys. Chem. C, 2009, 113, 3455.
[145] S. B. Zhang, S. H. Wei and A. Zunger, Phys. Rev. B, 1998, 57, 9642.
[146] H. Zhong, Y. Zhou, M. Ye, Y. He, J. Ye, C. He, C. Yang and Li, Y. Chem. Mater. 2008, 20, 6434.
[147] R. G. Pearson, J. Am. Chem. Soc. 1963, 85, 3533.
[148] Y. Y. Chen, S. J. Li, L. J. Huang and D. C. Pan, Inorg. Chem., 2013, 52, 7819.
[149] K. T. Kuo, S. Y. Chen, B. M. Cheng and C. C. Lin, Thin Solid Films, 2008, 517, 1257.
[150] J. Park and S. W. Kim, J. Mater. Chem., 2011, 21, 3745.
[151] F. Muhammad, M. Guo, Y. Guo, W. Qi, F. Qu, F. Sun, H. Zhaod and G. Zhu, J. Mater. Chem., 2011, 21, 13406.
[152] R. L. Momparler, M. Karon, S. E. Siegel and F. Avila, Cancer Res.,1976, 36, 2891.