3D ( Three Dimensional)列印技術因具客製化及擅長製作複雜形狀實體的特性而盛行聞名，尤其是光固化系統的解析度與精細度更是獨佔鰲頭，常被應用於生醫領域，此時在此系統中的光敏樹脂扮演了舉足輕重的角色。然而，現今光聚合的材料生物相容性多不佳，難以在臨床上被應用。在本實驗中，則採用臨床常用的高生物相容性寡聚物進行末端改質進而開發新型快速成型的光敏樹脂，寡聚物末端經由酯化作用接上不同密度的光反應官能基碳碳雙鍵(C=C)，使之聚合後的交聯密度不同，同時可藉由混和具生物相容性的稀釋劑或交聯劑調整聚合物的黏度以及機械性質，配方比例的調配不同以往的作法是可先將混合物的機械性質表現先利用Kwei或Gordon-Taylor equation進行預測，縮短試誤法所耗費的時間與原料，且在本實驗系統中，楊氏係數的調整範圍可由300kPa至2.8GPa，應用範圍相當廣泛。與商業化牙材相比，不論是生物相容性，又或者機械性質的表現都超越許多。

The technology of 3D printing is well-known for offering customized service and being good at complex shaping. Especially, the light curing system including DLP (Digital Light Processing) and SLA (Stereolithography Apparatus) shows the excellent resolution and accuracy allowing applications in biomedical field. Besides, the photo-resin plays an important role in the ligh curing system. However, most of photo-resins used now are not biocompatible enough and their mechanical properties are not well-controlled. In this research, in order to develope novel photo-resin for rapid prototyping, biocompatible oligomers approved by FDA were modified by grafting photo-reactive functional groups C=C at the ends of the chains. At the same time, the density of photo-reactive groups was controlled by applying different oligomer compositions. Additionally, we could also adjust the rheology and mechanical propertie of resin by blending with several monomers or crosslinkers. Moreover, Kwei and Gorden-Taylor equations were used to predict the mechanical strength of photo-cured resins systematically. In this study, the Young’s modulus was able to to be controlled from 300kPa to 2.8GPa, which was more superior to commercial resins. The culture of 7F2 and L929 also indicated that the photo-resin was very biocompatible with controllable cell affinity.

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